Recombinant Saccharomyces cerevisiae DER1-like family member protein 1 (DFM1)

in vitro E.coli expression system

中文名稱：

釀酒酵母DFM1重組蛋白
貨號：

CSB-CF615531SVG
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

DFM1
Uniprot No.：

Q12743
別名：

DFM1; YDR411C; D9461.2; DER1-like family member protein 1
種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
蛋白長度：

full length protein
表達區域：

1-341
氨基酸序列

MAGPRNVRTLHGNGGRNNDVMGPKEFWLNIPPITRTLFTLAIVMTIVGRLNLINPWYFIY VWNLTFKKVQIWRLLTSCVMLSSRAMPALMELYSIYDRSSQLERGHFGPGLSNRRGPMVT VDYAYYLCFCILAITTATTIIYGSYYPVVLTSGFISCITYTWSIDNANVQIMFYGLIPVW GKYFPLIQLFISFVFNEGDFVISLIGFTTGYLYTCLDTHTLGPIWGMISRKADPTYGISP NGKFSTPWWFTSLYARITGAHNETATFNNNFANVPSSQRETRTFSGRGQRLGTAPATLSQ TSGTDSGRASGSQLRSGPSNLNQFQGRGQRVGQTNSPSDSQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

May be involved in the degradation process of some misfolded endoplasmic reticulum (ER) luminal proteins. Its precise role is however unclear and its inability to complement der1 mutations, suggests either that it is not involved in degradation process of misfolded proteins, or that it participates in the destruction of specific misfolded ER luminal proteins.
基因功能參考文獻：
1. Results show Ypf1 is an Endoplasmic Reticulum-resident aspartyl intramembrane protease with a presenilin fold, and identified Doa10 and Dfm1 as its cofactors. PMID: 25454947
2. Dfm1 was part of complexes which contain the ERAD-L ligase Hrd1/Der3 and Der1 as well as the ERAD-C ligase Doa10. Dfm1 forms a complex with the AAA-ATPase Cdc48 in a strain lacking the Cdc48 membrane-recruiting component Ubx2. PMID: 20579315
3. Dfm1p degradation complex contains the Cdc48p cofactors Ubx1p and Ubx7p PMID: 18407841
亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

Derlin family
數據庫鏈接：

KEGG: sce:YDR411C

STRING: 4932.YDR411C