Recombinant Rat Type-1 angiotensin II receptor-associated protein (Agtrap)

in vitro E.coli expression system

中文名稱：

Recombinant Rat Type-1 angiotensin II receptor-associated protein(Agtrap)
貨號：

CSB-CF727055RA
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Agtrap
Uniprot No.：

Q642A2
別名：

Agtrap; Atrap; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-160
氨基酸序列

MELPAVNLKVILLVHWLLTTWGCLAFSGSYAWGNFTILALGVWAVAQRDSVDAIGMFLGG LVATIFLDIIYISIFYSSVAVGDTGRFSAGMAIFSLLLKPFSCCLVYHMHRERGGELPLR SDFFGPSQEHSAYQTIDSSDSPADPLASLENKGQAAPRGY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3.
基因功能參考文獻：
1. A single dose of angiotensin(17) at the same concentration as angiotensin II induced Agtrap gene expression. PMID: 26018598
2. The expression of both angiotensin AGTRa and AGTR2 receptors was increased in the myocardium of overfed rats, and ischemia-reperfusion increased the expression of both receptors in control rats but reduced it in overfed rats. PMID: 23383303
3. AT(1)-AB induces Ang II sensitivity. Our mechanistic study supports the existence of an "autoimmune-activating receptor" that could contribute to Ang II sensitivity and possible to preeclampsia. PMID: 21576625
4. results suggest that the local renin-angiotensin system is activated in diabetic skin and Angiotensin II receptors type 1 and 2 are likely to mediate the pathological changes of diabetic skin PMID: 21484513
5. These results show that adipocyte-derived angiotensin II is critically involved in perivascular adipose tissue-mediated potentiation of vasoconstriction in mesenteric arteries. PMID: 20156432
6. Long-term selective Ang II blockade ameliorates insulin resistance in adipose tissue from a model of metabolic syndrome. PMID: 19901849
7. The growth inhibitory effects of ATRAP might be due to interfering with angiotensin 1 receptor activation in vascular smooth muscle cell growth. PMID: 17441313
8. ATRAP promotes internalization of AT1R and attenuates the angiotensin II-mediated c-fos-transforming growth factor-beta pathway and proliferative response in vascular smooth muscle cells, suggesting a strategy to inhibit vascular fibrosis and remodeling PMID: 17875818
9. Angiotensin II distinctly upregulated TLR4 expression in the cells. PMID: 19471094
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亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
數據庫鏈接：

KEGG: rno:298646

STRING: 10116.ENSRNOP00000011747

UniGene: Rn.8471