Recombinant Rabbit Secretin receptor (SCTR)

in vitro E.coli expression system

中文名稱：

小圓錐花果SCTR重組蛋白
貨號：

CSB-CF020865RB
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

SCTR
Uniprot No.：

O46502
別名：

SCTR; Secretin receptor; SCT-R
種屬：

Oryctolagus cuniculus (Rabbit)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

22-445
氨基酸序列

HLVGAPPRLCDVLWVLQEERDQCLQELERERLGEEQPVPGCQGLWDNVSCWPSSAPGRMV ELECPRFLRMLTNSNGSLFRNCTQDGWTETFPRPDLACGVSMNDSSHERQHAYLLKLKVM YTVGYSSSLVMLLVALGILCAFRRLHCTRNYIHMHLFLSFILRALSNFIKDAVLFSSDDA IHCDAHRVGCKLVMVFFQYCIMANYAWLLVEGLYLHSLLVVSFFSERKCLQGFVVLGWGS PAMFVTSWAVTRHFLEDSGCWDINANAAIWWVIRGPVILSILINFILFINILRILTRKLR TQETRGQDMNHYKRLARSTLLLIPLFGVHYIVFVFSPEGAMEIQLFFELALGSFQGLVVA VLYCFLNGEVQLEVQKKWQQWHLWEPPLCPVALSSSFSNGTSSLNSTKACPSGRSRDTCK VSII
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity.
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 2 family
數(shù)據(jù)庫鏈接：

KEGG: ocu:100008671

STRING: 9986.ENSOCUP00000006668

UniGene: Ocu.2214