Recombinant Mouse Thrombomodulin (Thbd)

in vitro E.coli expression system

中文名稱：

小鼠Thbd重組蛋白
貨號：

CSB-CF023486MO
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Thbd
Uniprot No.：

P15306
別名：

Thbd; Thrombomodulin; TM; Fetomodulin; CD antigen CD141
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

17-577
氨基酸序列

LSALAKLQPTGSQCVEHECFALFQGPATFLDASQACQRLQGHLMTVRSSVAADVISLLLSQSSMDLGPWIGLQLPQGCDDPVHLGPLRGFQWVTGDNHTSYSRWARPNDQTAPLCGPLCVTVSTATEAAPGEPAWEEKPCETETQGFLCEFYFTASCRPLTVNTRDPEAAHISSTYNTPFGVSGADFQTLPVGSSAAVEPLGLELVCRAPPGTSEGHWAWEATGAWNCSVENGGCEYLCNRSTNEPRCLCPRDMDLQADGRSCARPVVQSCNELCEHFCVSNAEVPGSYSCMCETGYQLAADGHRCEDVDDCKQGPNPCPQLCVNTKGGFECFCYDGYELVDGECVELLDPCFGSNCEFQCQPVSPTDYRCICAPGFAPKPDEPHKCEMFCNETSCPADCDPNSPTVCECPEGFILDEGSVCTDIDECSQGECFTSECRNFPGSYECICGPDTALAGQISKDCDPIPVREDTKEEEGSGEPPVSPTPGSPTGPPSARPVHSGVLIGISIASLSLVVALLALLCHLRKKQGAARAELEYKCASSAKEVVLQHVRTDRTLQKF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
基因功能參考文獻：
1. macrophage infiltration and neointima formation following arterial ligation-induced vascular injury were higher in wild-type than in myeloid-specific thrombomodulin-deficient mice PMID: 27808085
2. discovery of a novel physiological function of thrombomodulin-dependent activated protein C generation within the CNS PMID: 27590316
3. The present study found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) possesses the cytoprotective function in association with an increase in levels of anti-apoptotic myeloid cell leukemia-1 protein in an activated protein C-independent PMID: 27427915
4. the lectin-like domain of thrombomodulin is critically involved in host defence against E. coli induced acute pyelonephritis PMID: 26573396
5. Identified Nur77/Nor1 as novel regulators of thrombomodulin expression and function in vascular endothelial cells. PMID: 26634653
6. TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF-BB. In addition, rTMD23 has therapeutic potential in corneal injury PMID: 25816372
7. Membrane-bound TM in macrophages plays an essential role in the development of abdominal aortic aneurysms by enhancing proinflammatory mediator elaboration, macrophage recruitment, and oxidative stress. PMID: 26338301
8. Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice PMID: 25860286
9. the recombinant epidermal growth factor-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice PMID: 25609841
10. Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells. PMID: 25497974
11. Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 and an independent mechanism. PMID: 24368584
12. The lectin-like domain of TM does not play an important role in the host response to M. tuberculosis infection in mice. PMID: 24136651
13. Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism. PMID: 24098750
14. TM has a critical role in skin differentiation and wound healing. PMID: 23321922
15. TM's lectin-like domain constrains glucose-induced complement activation on endothelial cells and podocytes and ameliorates albuminuria and glomerular damage. PMID: 23014597
16. FFAs inhibit TM-EPCR-Protein C system in endothelial cells through activating JNK signaling, which may be a mechanism for the prothrombotic state in metabolic syndrome. PMID: 22903729
17. Genetic or acquired thrombomodulin defects might have an impact on the severity of microangiopathic lesions after exposure to Shiga toxin-producing E. coli infections. PMID: 22942429
18. we conclude that monocytic membrane-bound thrombomodulin participates in the LPS- and gram-negative bacteria-induced inflammatory response. PMID: 22573811
19. Recombinant thrombomodulin domains 2 and 3 protein significantly reduces atherosclerosis and neointima formation through its thrombin-binding ability. PMID: 21840881
20. RHBDL2 and soluble thrombomodulin were upregulated in ex vivo tissue culture of injured mouse skin. 3,4-Dichloroisocoumarin inhibited thrombomodulin production and wound healing; this was reversed by recombinant thrombomodulin in mice. PMID: 21833011
21. Mutations in Thrombomodulin is associated with metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. PMID: 21788337
22. During cardiac hypertrophy, thrombomodulin treatment decreases cardiomyocyte apoptosis and maintains left ventricular contractile function in response to pressure overload. PMID: 21111988
23. Thrombomodulin and platelet-derived growth factor receptor alpha (PDGFRalpha) identify a population of fibroblastic reticular cells in lymph nodes where chemokine secretion is controlled by junction adhesion molecule 3 protein (JAM-C). PMID: 21685324
24. Paclitaxel downregulates thrombomodulin expression in aortic endothelial cells. PMID: 21423464
25. Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. PMID: 20348393
26. lectin-like domain of TM interferes with polymorphonuclear leukocyte adhesion to ECs by intercellular adhesion molecule 1-dependent and -independent pathways through the suppression of extracellular signal-regulated kinase activation PMID: 12208873
27. These findings show a new function for the thrombomodulin-protein C system in controlling the growth and survival of trophoblast cells in the placenta, which is essential for the maintenance of pregnancy. PMID: 12579195
28. Deficiency in TM results in enhanced thrombus formation in a murine model of carotid artery thrombosis and support a role for TM defects in arterial thrombotic disease PMID: 14556079
29. thrombomodulin generates activated protein C but does not play a role in the pulmonary response to respiratory pathogens or lipopolysaccharide PMID: 14592828
30. thrombomodulin has an antimetastatic role in reducing cell proliferation and enhancing Ca2+-independent cell aggregation PMID: 15448005
31. surviving Thrombomodulin activated protein C generation mice displayed increased lung inflammation accompanied by higher mycobacterial loads in liver and spleen PMID: 16014564
32. analysis of the role of TM in modulating innate immunity PMID: 16879225
33. peripheral clock in vascular endothelial cells regulates TM gene expression and that the oscillation of TM expression may contribute to the circadian variation of cardiovascular events PMID: 17848551
34. Par4 deficiency of the mother, or the absence of maternal platelets, restores normal development in one-third of Thbd-null embryos PMID: 18490515
35. the lectin-like domain of thrombomodulin protects against ischaemia-reperfusion lung injury PMID: 18508817
36. Ets-1 mediates platelet-derived growth factor-BB-induced thrombomodulin expression in human vascular smooth muscle cells. PMID: 19091791
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Endothelial cells are unique in synthesizing thrombomodulin.
數據庫鏈接：

KEGG: mmu:21824

STRING: 10090.ENSMUSP00000096877

UniGene: Mm.24096