Recombinant Mouse Interleukin-1 receptor-like 1 (Il1rl1)

in vitro E.coli expression system

中文名稱：

小鼠Il1rl1重組蛋白
貨號：

CSB-CF011626MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

Il1rl1
Uniprot No.：

P14719
別名：

Il1rl1; Ly84; St2; Ste2; Interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Lymphocyte antigen 84; Protein ST2; Protein T1
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

27-567
氨基酸序列

SKSSWGLENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYACVIRSPNLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTAPVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINKTVVGNFGEARIQEEEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALNLHGMIRHTIRLRRKQPIDHRSIYYIVAGCSLLLMFINVLVIVLKVFWIEVALFWRDIVTPYKTRNDGKLYDAYIIYPRVFRGSAAGTHSVEYFVHHTLPDVLENKCGYKLCIYGRDLLPGQDAATVVESSIQNSRRQVFVLAPHMMHSKEFAYEQEIALHSALIQNNSKVILIEMEPLGEASRLQVGDLQDSLQHLVKIQGTIKWREDHVADKQSLSSKFWKHVRYQMPVPERASKTASVAAPLSGKACLDLKHF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.; Inhibits IL-33 signaling.
基因功能參考文獻(xiàn)：
1. Taken together, our data provide the evidence that ST2 deficiency in early phase of sepsis downregulates myeloid precursors, inflammatory NK and dendritic cells PMID: 30001716
2. Studied the association of interleukin 1 receptor-like 1 deficiency (St2) on renal ischaemia-reperfusion injury in euglycaemic and hyperglycaemic mice. PMID: 28916390
3. sST2 is downregulated in high-metastatic cells compared with low-metastatic human and mouse CRC cells. Knockdown of sST2 in low-metastatic cells enhances tumour growth, metastasis and tumour angiogenesis, whereas its overexpression in high-metastatic cells suppresses these processes. PMID: 27882929
4. IL-33/ST2 can induce production of proinflammatory cytokines, such as TNF-alpha and IL-6, through production of IL-13 in Plasmodium chabaudi-infected BALB/c mice, suggesting that IL-33/ST2 play a critical role in inflammatory responses to malaria infection. PMID: 28359899
5. these results provide new insights into the mechanisms by which intestinal epithelial cells , via IL-33/ST2 axis, may control pro-inflammatory TH17 cells in the small intestine to sustain homeostasis PMID: 28198366
6. Results indicate that IL-33/ST2 signaling is functionally present in primary sensory neurons and contributes to pruritus in poison ivy ACD. Blocking IL-33/ST2 signaling may represent a therapeutic approach to ameliorate itch and skin inflammation related to poison ivy allergic contact dermatitis. PMID: 27821781
7. CLOCK temporally gates mast cell responses to IL-33 via regulation of ST2 expression. Our findings provide novel insights into IL-33/mast cell-associated physiology and pathologies. PMID: 28259547
8. an increased prevalence in neonatal mortality was observed in litters from dams lacking ST2 PMID: 29133293
9. Taken together, the data demonstrate a critical role of MyD88 in DCs and of IL-33 signaling via ST2 in MC903-induced Atopic dermatitis (AD). These data suggest that IL-33/IL-33R may be a therapeutic target of AD. PMID: 28383552
10. Heligmosomoides polygyrus Alarmin Release Inhibitor (HpARI) prevents binding of active interleukin-33 (IL-33) to the IL-33 receptor. PMID: 29045903
11. mice deficient in the receptor for IL-33 (Il1rl1-/-) demonstrated enhanced lung clearance of Aspergillus fumigatus PMID: 28784844
12. This stuidy shown that the mRNA expression of IL-33 and ST2 receptors is increased in the CNS of Rocio virus-infected WT mice and that ST2(-/-) mice showed increased susceptibility to infection. PMID: 27334012
13. Liver Treg cells show a high expression of ST2, a cellular receptor for tissue alarmin IL-33, which is strongly upregulated in the liver of infected mice. These results illustrate the importance of IL-33 in the suppressive function of liver Treg cells during Cytomegaloviruses (CMVs) infection. PMID: 28448566
14. These results shed light on endogenous IL-33/ST2 signaling as a potential immune regulatory mechanism that serves to promote beneficial microglial responses and mitigate ischemic brain injury after stroke. PMID: 28389473
15. Plasmodium berghei infection triggered a dramatic increase of IL-33 expression by oligodendrocytes, through ST2 pathway. PMID: 28448579
16. Data, including data from studies using knockout mice, suggest that signal transduction via IL33/ST2L (interleukin 33/interleukin-33 receptor) plays a cardioprotective role in myocardial remodeling under mechanical stress (which leads to left ventricular hypertrophy and heart failure). PMID: 28450225
17. IL-33 acts as a potent immune modulator protecting the liver through activation of ST2(+) Treg cells and control of natural killer cells in immune cell-mediated hepatitis. PMID: 27340126
18. IL-33/ST2 pathway plays a role in enhancing inflammation and tissue damage at the site of acute inflammation. PMID: 27222019
19. this study shows that the functional IL-33R is expressed on eosinophil progenitors, basophil progenitors and mast cell progenitors PMID: 27568595
20. the present study hypothesized that IL-33, as a 'master switch' of tissue repair that is secreted from dying or apoptotic cells, activated the IL-33-ST2-MyD88-TRAF6 pathway, amplified Th2-type responses and was involved in the pulmonary fibrosis process, via its receptor ST2, a stable marker of Th2 cells. PMID: 27358001
21. ST2 deletion increases inflammatory bone loss in experimental periapical lesions in mice. PMID: 25595464
22. ST2 receptor invalidation maintains wound inflammation, delays healing and increases fibrosis PMID: 26314835
23. the results of the present study suggest a possible asthma phenotype that involves the IL-33/ST2 pathway and is important for the development of airway inflammation and AHR in the peripheral airways. PMID: 26609909
24. Data suggest that IL-33 and ST2 function as a developmental switch to license thermogenesis during the perinatal period. PMID: 27453471
25. The IL-33/ST2 axis may play a crucial role in the pathogenesis of angiostrongylosis. PMID: 24657070
26. Blockade of ST2 markedly improves survival of lymphocytic choriomeningitis virus -infected Prf1-/- mice and reduces the severity of multiple disease parameters, including serum levels of IFNgamma. PMID: 26518437
27. the IL-33/ST2 axis specifically controls visceral adipose tissue-Treg cell development was revealed. PMID: 26277897
28. The activity of IL-33 at its receptor ST2 is terminated by the formation of two disulphide bridges, resulting in conformational change that disrupts the ST2 binding site. PMID: 26365875
29. IL-33/ST2 may involve the regulation of ocular immunopathology induced by Toxoplasma gondii infection. PMID: 25693767
30. ST2/IL-33 signaling contributes to neuropathic pain by activation of astroglial JAK2-STAT3 cascade and neuronal CaMKII-CREB cascade. PMID: 26352378
31. IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection. PMID: 25926677
32. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. PMID: 25814531
33. role of the IL-33/ST2 pathway in Plasmodium berghei experimental cerebral malaria development PMID: 25682948
34. Results indicate that IL-33/ST2 signalling is involved in respiratory syncytial virus (RSV)-induced, Th2-associated airway inflammation but not protective immunity. PMID: 25721734
35. These results suggest that modulation of the ST2L internalization by FAK/GSK3beta might serve as a unique strategy to lessen pulmonary inflammation. PMID: 25472995
36. IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice PMID: 24985397
37. ST2 does not impair the establishment of adult L. sigmodontis worms, but is important for the splenic clearance of microfilariae from peripheral blood. PMID: 24663956
38. Together, these data reveal a cell-intrinsic role for the IL-33/ST2 axis in the regulation of apoptosis in MC, identifying thereby a previously unappreciated pathway supporting expansion of the MC population with inflammation. PMID: 24982172
39. IL-33/ST2 signalling triggers the production of inflammatory mediators contributing to carrageenin-induced inflammation; this reinforces the importance of IL-33/ST2 signalling as a target in innate inflammation and inflammatory pain PMID: 23347081
40. These data further suggested that IL-33/ST2 signaling played a vital role in cancer pain. PMID: 23988433
41. ST2 augments rather than inhibits cytokine release by blood leukocytes and splenocytes exposed to S. pneumoniae or K. pneumoniae, but plays a limited role in host defense during sepsis caused by these pathogens. PMID: 23856919
42. Which was attenuated in the absence of ST2. PMID: 24105680
43. The IL-33 and ST2 suppresses Th1 responses in the livers of BALB/c mice infected with Leishmania donovani. PMID: 24045639
44. Bee venom PLA2-induced innate lymphoid cells & primary Th2 responses were dependent on ST2. The IgE response was largely unaffected by ST2-deficiency, possibly because ST2 is required for primary but not secondary T cell responses. PMID: 24210353
45. The role of ST2 differs between different target tissues: ST2 is dispensable for the development of Th2 response in the sensitized skin, whereas it is a main inducer of Th2 cytokines in asthmatic airways. PMID: 23633023
46. These data suggest IL-33 and its ST2 receptor mediate formalin-induced inflammatory pain PMID: 23523996
47. Mice deficient in IL-33R significantly develop more severe pancreatitis, have greater weight loss, and contain higher viral load compared with wild-type mice. PMID: 23733876
48. ST2 plays a limited anti-inflammatory role during both primary influenza and postinfluenza pneumococcal pneumonia. PMID: 23483993
49. T1/ST2 directs Th2 cell activation and polyfunctionality in allergic bronchopulmonary mycosis. PMID: 22990621
50. Il-33/ST2 activation in HESCS drives an autoinflammatory response that controls the temporal expression of receptivity genes PMID: 23300625
顯示更多

收起更多
亞細(xì)胞定位：

Cell membrane; Single-pass type I membrane protein.; [Isoform B]: Secreted.
蛋白家族：

Interleukin-1 receptor family
組織特異性：

Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Isoform A is expressed in brain astrocytes and microglia. Isoform B is expressed in brain endothelial cells.
數(shù)據(jù)庫鏈接：

KEGG: mmu:17082

STRING: 10090.ENSMUSP00000054914

UniGene: Mm.289824