Recombinant Mouse Claudin-6 (Cldn6)-VLPs (Active)

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品名簡稱：

Recombinant Mouse Cldn6 protein-VLPs (Active)
貨號(hào)：

CSB-MP3347MO
說明書：

MSDS Datasheet
規(guī)格：

￥4000
圖片：
CSB-MP3347MO is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6 at 5 μg/ml can bind Anti-CLDN6/9 recombinant antibody(CSB-RA005508MA1HU). The EC₅₀ is 4.027-6.270 ng/mL.The VLPs (CSB-MP3838) is negative control. Biological Activity Assay

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6 at 5 μg/ml can bind Anti-CLDN6/9 recombinant antibody(CSB-RA005508MA3HU). The EC₅₀ is 7.349-12.12 ng/mL.The VLPs (CSB-MP3838) is negative control. Biological Activity Assay

The purity of VLPs was greater than 95% as determined by SEC-HPLC
促銷：
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 95% as determined by SEC-HPLC.
內(nèi)毒素：

Less than 1.0 EU/ug as determined by LAL method.
生物活性：

①M(fèi)easured by its binding ability in a functional ELISA. Immobilized Mouse cldn6 at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody(CSB-RA005508MA1HU). The EC50 is 4.027-6.270 ng/mL.The VLPs (CSB-MP3838) is negative control. ②Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6 at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody(CSB-RA005508MA3HU). The EC50 is 7.349-12.12 ng/mL.The VLPs (CSB-MP3838) is negative control.
基因名：

Cldn6
Uniprot No.：

Q9Z262
別名：

Claudin-6; Skullin; Cldn6
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length
來源：

Mammalian cell
分子量：

24.8 kDa
表達(dá)區(qū)域：

1-219aa
氨基酸序列

MASTGLQILGIVLTLLGWVNALVSCALPMWKVTAFIGNSIVVAQMVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVVTLLIVLLGLLVYLAGAKCTTCVEDRNSKSRLVLISGIIFVISGVLTLIPVCWTAHSIIQDFYNPLVADAQKRELGASLYLGWAASGLLLLGGGLLCCACSSGGTQGPRHYMACYSTSVPHSRGPSEYPTKNYV
蛋白標(biāo)簽：

C-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions)
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
基因功能參考文獻(xiàn)：
1. Cldn6 was markedly decreased in the lungs of mice exposed to acute tobacco sm PMID: 27982694
2. These data reveal captivating information suggesting a role for Cldn6 in lungs exposed to tobacco smoke and suggest that further research is necessary in order to fully explain roles for tight junctional components such as Cldn6 PMID: 27763528
3. Over-expression of Claudin 6 during embryogenesis delays lung morphogenesis. PMID: 26198145
4. Cldn6 is expressed by pulmonary epithelium during lung organogenesis. PMID: 24970044
5. The Inv-Cldn6-CDelta206 transgenic mice displayed a developmental delay in epidermal permeability barrier formation, as shown by the expression of keratins and Cldns, and by X-Gal penetration assays. PMID: 20106878
6. the normally robust injury response mechanism of the epidermis is lost in the aging Involucrin-Cldn6-CDelta196 transgenic epidermis PMID: 19915705
7. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. PMID: 11923212
8. Cldn6 plays a role in the differentiation processes of the epidermis and hair follicle PMID: 15908185
9. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 ce PMID: 16306693
10. developmentally expressed claudin isoforms include claudin 6, claudin 9, and claudin 13 PMID: 16774906
11. Results demonstrate that the overexpression of a tail truncation mutant of claudin 6 (Cldn6) mislocalizes Cldn6 and other Cldn proteins to the cytoplasm and triggers a postnatal increase in proliferation and aberrant differentiation of the epidermis. PMID: 16847338
12. Tight junctions containing claudin 6 are essential for blastocyst formation in preimplantation mouse embryos PMID: 17980358
13. A lineage analysis of the fate of Cldn6-expressing embryonic endoderm cells is relevant to the development of the pancreas, lung, and liver. PMID: 18213590
14. Expression analysis in mice has shown that Claudin-6 is one of the few genes that allows for the targeting of the definitive endoderm throughout the entire anterior-posterior axis, before and after gut tube patterning. PMID: 18213590
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亞細(xì)胞定位：

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Claudin family
組織特異性：

Expressed mostly in embryonic tissues.
數(shù)據(jù)庫鏈接：

KEGG: mmu:54419

STRING: 10090.ENSMUSP00000024699

UniGene: Mm.86421