Recombinant Mouse Cation-dependent mannose-6-phosphate receptor (M6pr)

in vitro E.coli expression system

中文名稱：

小鼠M6pr重組蛋白
貨號：

CSB-CF013293MO
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

M6pr
Uniprot No.：

P24668
別名：

M6pr; 46mpr; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

22-278
氨基酸序列

VRESWQIEEKSCDLVGEKDKESKNEVALLERLRPLFNKSFESTVGQGSDTYSYIFRVCREASNHSSGAGLVQINKSNDKETVVGRINETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLAANFNPVSEERGKVQDCFYLFEMDSSLACSPEVSHLSVGSILLVIFASLVAVYIIGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
基因功能參考文獻：
1. Finally, Chlamydia trachomatis infection interferes with the SNX5:cation-independent mannose-6-phosphate receptor interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor are dependent on the same binding surface on SNX5. PMID: 28252385
2. We conclude that M6PR is an important receptor used by HIV-1 to cross the blood-brain barrier. PMID: 22761827
3. Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice PMID: 20407205
4. Mannose 6-phosphate receptor has a role in acid sphingomyelinase deficiency PMID: 14557264
5. in hepatocytes of MPR-deficient neonatal mice lysosomal storage occurs when both MPRs are lacking, whereas deficiency of CI-MPR only has no effect on the ultrastructure of the lysosomal system. PMID: 14585283
6. Data characterize the retrograde transport of mannose 6-phosphate receptor MPR46 from endosomes to the trans-Golgi network by an in vitro transport assay using mouse fibroblast cell lines. PMID: 14617361
7. there is not a an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing in internalization of monomeric and complexed granzyme B PMID: 14985351
8. These results indicate that beta-glucuronidase transport into brain parenchyma in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II receptor. PMID: 15314220
9. Mpr46 is dispensable on target cells for lysis and apoptosis mediated by alloreactive cytotoxic T lymphocytes. PMID: 15371683
10. The murine 46-kDa mannose 6-phosphate receptor has the capacity to deliver its cargo proteins to lysosomes even in the absence of endosomal acidification. PMID: 17105763
11. epinephrine restores the M6P receptor-mediated functional transport of (131)I-P-beta-glucuronidase across the blood brain barrier in adults to levels seen in the neonate PMID: 17646643
12. the alpha-galactosidase enzyme is incorporated via cation-independent mannose 6-phosphate receptors in Schwann cells PMID: 17965825
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亞細胞定位：

Lysosome membrane; Single-pass type I membrane protein.
數據庫鏈接：

KEGG: mmu:17113

STRING: 10090.ENSMUSP00000007602

UniGene: Mm.249225