Recombinant Human Sodium/potassium-transporting ATPase subunit beta-2 (ATP1B2)

in vitro E.coli expression system

中文名稱：

Recombinant Human Sodium/potassium-transporting ATPase subunit beta-2(ATP1B2)
貨號：

CSB-CF002327HU
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

ATP1B2
Uniprot No.：

P14415
別名：

ATP1B2; Sodium/potassium-transporting ATPase subunit beta-2; Adhesion molecule in glia; AMOG; Sodium/potassium-dependent ATPase subunit beta-2
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-290
氨基酸序列

MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINKT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.; Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
基因功能參考文獻：
1. The AMOG expression pattern with altered cellular distribution observed in malformations of cortical development suggests that AMOG might contribute to abnormal cortical development via mTOR activation. PMID: 20656459
2. analysis of pathways for maturation of the Na,K-ATPase beta1 and beta2 subunits in the endoplasmic reticulum PMID: 20937802
3. The strong expression of AMOG within the precursor cells of gangliogliomas may represent an additional marker for the diagnostic evaluation of these glioneuronal lesions PMID: 19371356
4. Results demonstrated that the sodium-potassium ATPase beta2 subunit (NKA1b2) was localized both in the neuronal cytoplasm and cellular membrane. PMID: 15294280
5. We identified interesting novel candidate genes that likely contribute to glioma progression and provide first evidence for a role of epigenetic silencing of AMOG in malignant glioma cells. PMID: 16865689
6. Common genetic variation in TP53 and its flanking genes (ATP1B2) found no significant overall associations between SNPs in TP53 and breast cancer risk PMID: 17683073
7. the ER quality control system allows export only of assembled alpha-beta complexes to the Golgi, whereas the number of alpha(1) subunits in the ER determines the amount of the alpha-beta complexes PMID: 19764716
8. different members of the Na,K-ATPase beta subunit family may have specialized functions. PMID: 2538450
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亞細胞定位：

Cell membrane; Single-pass type II membrane protein.
蛋白家族：

X(+)/potassium ATPases subunit beta family
數據庫鏈接：

HGNC: 805

OMIM: 182331

KEGG: hsa:482

STRING: 9606.ENSP00000250111

UniGene: Hs.643540