Recombinant Human Aquaporin-7 (AQP7)-VLPs

中文名稱：

Recombinant Human Aquaporin-7 (AQP7)-VLPs
貨號：

CSB-MP001967HU
說明書：

MSDS Datasheet
規格：
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

AQP7
Uniprot No.：

O14520
別名：

AQP-7;Aquaglyceroporin-7;Aquaporin adipose;AQPap;Aquaporin-7-like
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

Mammalian cell
表達區域：

1-342aa
氨基酸序列

MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITVLPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 10xHis-tagged
If you have specified tag type, please tell us and we will check if it's possible to develop.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from PBS, 6% Trehalose, pH 7.4.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事項：

The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney.
基因功能參考文獻：
1. ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation PMID: 27832861
2. a direct involvement of AQP7 in water and glycerol transport PMID: 24376702
3. AQP7-specific glycerol transport was furthermore found to be specifically inhibited. PMID: 24334538
4. REVIEW: the current knowledge on the role of the glycerol channels AQP7 and AQP9 in controlling glycerol metabolism in adipose tissue and liver PMID: 24463099
5. AQP7 overexpression may be related to insulin sensitivity and glucose homeostasis in women with the polycystic ovary syndrome. PMID: 23235401
6. AQP7 is expressed in human and mouse oocytes and upregulated by cryoprotectants. PMID: 23290745
7. AQP7 is regulated in response to physical training in a gender-dependent manner in adipose tissue. PMID: 23001483
8. The discovery of an association between urine glycerol loss and a platelet secretion defect is a novel one, and our findings imply the involvement of AQPs in platelet secretion. PMID: 22899094
9. There is a coordinated regulation of adipose AQP7 and hepatic AQP9 gene expression that is distorted in metabolic syndrome X. PMID: 22425521
10. In all of the 33 investigated semen samples, we observed AQP7 binding to the sperm sur-face with different intensity and modality. PMID: 22206455
11. Diazoxide may have an impact on myocardial water balance and glycerol energy supply by decreasing relative aquaporin-7 expression during coronary artery bypass grafting. PMID: 21609198
12. these data suggest a subtle regulation between adipose depots of the sole adipose aquaporin, AQP7, which is unbalanced in obesity and T2D. PMID: 20463097
13. determination of genomic structure, promotor analysis and functional mutation PMID: 11952783
14. In summary, our data show that the AQP7 gene is differentially expressed in adipose tissue of lean and obese individuals. PMID: 16325777
15. AQP7 downregulation is pathogenic for obesity and/or type 2 diabetes. PMID: 17351148
16. Dysfunction of AQP7 in the periadventitial fat may trigger the inflammation involved in aatherosclerosis. PMID: 17562358
17. Expression of AQP7 is down-regulated in women with severe obesity. The expression of this glycerol channel is not affected by type 2 diabetes. PMID: 17566090
18. increased gene expression in visceral adipose tissue and liver in morbid obesity PMID: 18401671
19. we found a greater expression found in visceral fat, and between subcutaneous adipose AQP7 and hepatic aquaporin 9 gene expression within the context of human morbid obesity PMID: 19615702
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cytoplasm, cell cortex. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lipid droplet.
蛋白家族：

MIP/aquaporin (TC 1.A.8) family
組織特異性：

Detected in the sperm head (at protein level). Detected in white adipose tissue.
數據庫鏈接：

HGNC: 640

OMIM: 602974

KEGG: hsa:364

STRING: 9606.ENSP00000297988

UniGene: Hs.455323