Recombinant Human 5-hydroxytryptamine receptor 1B (HTR1B)

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中文名稱：

人HTR1B重組蛋白
貨號：

CSB-CF010882HUb0
說明書：

MSDS Datasheet
規格：

￥9720
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

HTR1B
Uniprot No.：

P28222
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

in vitro E.coli expression system
分子量：

45.1 kDa
表達區域：

1-390aa
氨基酸序列

MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
基因功能參考文獻：
1. Involvement of HTR1B variants in ADHD susceptibility as well as in externalizing and internalizing comorbidities, considering sex differences. PMID: 28923721
2. The polymorphism of HTR1B C861G is not a risk factor for Tourette's in Han Chinese population. PMID: 26123080
3. Acute tryptophan depletion (ATD) did not significantly influence participants' sensitivity to probability, wins, or losses, although there was a trend for a lower tendency to choose experimental gambles overall following depletion. Following ATD, participants with higher peripheral 5-HT1B transcription levels increased choice of experimental gambles and used information pertaining to possible wins more when making choices PMID: 27638901
4. This study found several promoter variants in linkage disequilibrium that may potentially influence the allelic imbalance in the C861G variant. aAnd no evidence of allelic imbalance nor parent-of-origin effects of the C861G variant was observed in suicidal behavior. PMID: 28445878
5. Single nucleotide polymorphism in HTR1B gene is associated with Attention deficit hyperactivity disorder. PMID: 28512748
6. nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls. No significant association was observed. PMID: 28176268
7. results highlight the importance of HTR1 in leukemogenesis and LSC survival and identify this receptor family as a new target for therapy in AML with prognostic value PMID: 28193998
8. HTR polymorphisms related to vulnerability to major depressive disorder (MDD) and MDD with suicidal attempts. PMID: 28007644
9. The results of this study give new evidence for the role of epigenetic and genetic factors which could modulate HTR1B expression in the pharmacological response to antidepressants. PMID: 28025020
10. 5-HT1B receptor-dependent cellular Src-related kinase-Nox1-pathways contribute to vascular remodeling in pulmonary arterial hypertension. PMID: 28473438
11. preliminary findings suggest a role of the HTR1B gene in susceptibility to development of bulimia nervosa subtypes. Furthermore, this gene might have an impact on the severity of anxiety in anorexia nervosa-spectrum patients. PMID: 27579596
12. Polymorphic variants of the HTR1B gene are associated with the susceptibility of secondary RP in vibration-exposed occupational populations of Chinese Han people. PMID: 26639766
13. large scale neural activation differences in the inferior and medial frontal and temporal/parietal regions of the response inhibition network between the different variants of both the HTR1B and 5HTT genes; activation in these regions was significantly associated with stop-task performance, but not with ADHD diagnosis or severity PMID: 26428549
14. Results from Parkinson's disease patients and MPTP-lesioned monkeys argue in favor of a contribution of 5-HT1B receptors in the pathophysiology of levodopa-induced motor complications PMID: 26254863
15. The interaction between two major serotonergic structures involved in serotonin release, the SERT and 5-HT1B receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-HT1A receptors. PMID: 25652393
16. Serotonin 1B Receptor Gene (HTR1B) Methylation as a Risk Factor for Callous-Unemotional Traits in Antisocial Boys PMID: 25993020
17. Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells. PMID: 25268648
18. reductions in 5-HT1B availability found in this study suggest that 5-HT1B receptors may contribute to the etiology or expression of cocaine dependence and potentially represent a target for medication development. PMID: 24433854
19. 5-HT1B- and 5-HT1D-mediated signaling play an important role in the regulation of the proliferative and invasive phenotype of pancreatic cancer cells. PMID: 25170871
20. Genetic variation in HTR1B predicts changes in bone metabolism during SSRI use. PMID: 24074042
21. HTR1B SNPs significantly associate with early-onset obsessive compulsive disorder. PMID: 24571444
22. Low level of 5-HT(1B)receptors in limbic system corelates to decreased serotonin function in patients with Parkinson disease.(review) PMID: 24126162
23. HTR1B SNP rs6296 was associated with childhood aggressive behavior but not with adulthood anger or hostility. The HTR1B SNP rs6296 modified the association between childhood aggressive behavior and adulthood hostility. PMID: 22945537
24. 5-HT inhibits pulmonary artery smooth muscle cell apoptosis via pERK1/2, PDK, 5-HT1B, 5-HTT pathway. PMID: 23601559
25. Alterations in 5HT1B-receptor density were found to be differentially linked to a novel, five-factor model of posttraumatic stress disorder symptoms. PMID: 22584868
26. An association between the sexual dimension of aging males' syndrome and genetic variants of 5-HTR1B G861C is observed. PMID: 23485949
27. Brain 5-HT1B receptor occupancy with zolmitriptan is demonstrated. PMID: 23430984
28. In a Turkish population of migraine patients no genetic association with 5-HT1B polymorphisms is found. PMID: 23375453
29. These results cannot provide support for an important function of TPH1 and HTR1B in the pathogenesis of sclerosing bone dysplasias. PMID: 23563356
30. This meta-analysis supports the associations of HTR1B -261T>G and -161A>T with alcohol and drug abuse and further investigations are warranted in larger samples. PMID: 23335468
31. The results of this study concluded that SSRIs reduce attention in older adults, particularly in those with high-expression genetic variants at the 1B receptors. PMID: 22717018
32. HTR1B genotypes AA & AT are associated with a lower age of onset of smoking in women than the TT genotype. PMID: 23177301
33. crystal structures of the 5-HT1B G protein-coupled receptor bound to the agonist antimigraine medications ergotamine and dihydroergotamine PMID: 23519210
34. Epistatic interactions between presynaptic components (5HTR1B and SLC6A4) as reported are likely to regulate serotonin levels in the synapse and impact treatment for ADHD. PMID: 22575343
35. The CC genotype of HTR1B G681C polymorphism had higher cortisol and prolactin responses and higher platelet-rich plasma serotonin in health volunteers but this was not observed in nonresponsive OCD with the same genotype after chronic SRI treatment. PMID: 22522758
36. age is a relevant factor for 5-HT(1B) in the cortex of healthy adults PMID: 22851636
37. Preliminary data imply that the genetic variants of the 5-HT1B receptor might be associated with prostate cancer PMID: 22420486
38. Neither the 5-HTTLPR gene nor the 5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan's Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism. PMID: 22550993
39. our findings point to an association between functional variants in the promoter region of the HTR1B gene and alcohol dependence, supporting previous neurobiological evidences of the involvement of HTR1B variations in alcohol-related phenotypes. PMID: 22005095
40. two SNPs, both serotonin receptor 5-HT(1B) linked, had a significant main effect on ejaculation latency time. PMID: 22240001
41. Selective inhibition of 5-HT2A by sarpogrelate stimulated angiogenesis, restoring ischemic limb blood perfusion in a severe diabetic mouse model through stimulation of the eNOS/Akt pathway via the endothelial 5-HT1B receptor. PMID: 22172591
42. There was a statistically significant association with Body Mass Index at HTR1B single nucleotide polymorphism rs4140535 in African Americans but not in Caucasians. PMID: 22106445
43. genetic association studies in Ireland/Northern Ireland: SNPs in HTR1B and OPRmu1 genes are associated with subgroups of subjects with alcohol dependence distinguished by age of onset. PMID: 21906503
44. These findings point to a role for HTR(1B) polymorphism in heroin dependence among Han Chinese, and may be informative for future genetic or neurobiological studies on heroin dependence. PMID: 21839728
45. Sumatriptan and tegaserod were more potent at the 124Cys-variant h5-HT1B receptor PMID: 21478802
46. findings suggest that allelic variability in SLC1A2/3, 5-HTR1B and NTRK2 may be relevant to the underlying diathesis for suicidal acts. PMID: 21711518
47. The HTR1B A-161T polymorphism may be particularly valuable as a functional genetic marker for alcoholis PMID: 21172311
48. our findings suggest abnormally reduced function of ventral striatum/ventral pallidum 5-HT1B receptors in humans with major depressive disorder PMID: 20480149
49. This study found haplotype of HTR1B gene that was significantly more frequent in worman then in mam. PMID: 20674037
50. There was no assocition of HTR1B with adolescent idiopathic scoliosis. PMID: 20388441
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.
數據庫鏈接：

HGNC: 5287

OMIM: 182131

KEGG: hsa:3351

STRING: 9606.ENSP00000358963

UniGene: Hs.123016