Recombinant Drosophila melanogaster Odorant receptor 22a (Or22a)

in vitro E.coli expression system

中文名稱：

黑腹果蠅Or22a重組蛋白
貨號：

CSB-CF305699DLU
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Or22a
Uniprot No.：

P81909
別名：

Or22a; AN11; DOR22A.1; dor53; Or22A.1; CG12193; Odorant receptor 22a
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

full length protein
表達區(qū)域：

1-397
氨基酸序列

MLSKFFPHIKEKPLSERVKSRDAFIYLDRVMWSFGWTEPENKRWILPYKLWLAFVNIVML ILLPISISIEYLHRFKTFSAGEFLSSLEIGVNMYGSSFKCAFTLIGFKKRQEAKVLLDQL DKRCLSDKERSTVHRYVAMGNFFDILYHIFYSTFVVMNFPYFLLERRHAWRMYFPYIDSD EQFYISSIAECFLMTEAIYMDLCTDVCPLISMLMARCHISLLKQRLRNLRSKPGRTEDEY LEELTECIRDHRLLLDYVDALRPVFSGTIFVQFLLIGTVLGLSMINLMFFSTFWTGVATC LFMFDVSMETFPFCYLCNMIIDDCQEMSNCLFQSDWTSADRRYKSTLVYFLHNLQQPITL TAGGVFPISMQTNLAMVKLAFSVVTVIKQFNLAERFQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses ethyl butyrate and to esters in more general. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide.
基因功能參考文獻：
1. The or22a neuron major projected into glomerulus of DM2 and less projected to VC1 and VC31. PMID: 12555270
2. odorant receptors thus form ligand-gated channels as well as complexes of odorant-sensing units and cyclic-nucleotide-activated non-selective cation channels PMID: 18408711
3. signals by opening cation channels, through a mechanism that is largely independent of G proteins PMID: 18625400
4. Data show that Or22a is expressed in approxiamately 25 olfactory sensory neurons and marks a small glomerulus, DM2. PMID: 18683641
5. Intraspecific study of 4 natural populations of D melanogaster survey showed a copy-number polymorphism in some of the populations, with the 2 genes, Or22a & Or22b in the long variant and a single chimeric gene, Or22ab present in the short variant. PMID: 18922763
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Insect chemoreceptor superfamily, Heteromeric odorant receptor channel (TC 1.A.69) family, Or2a subfamily
組織特異性：

Expressed with Orco in 17-20 sensory neurons on the medial-proximal edge of the antenna. Expressed in the ab3A neuron which responds to ethyl butyrate.
數(shù)據(jù)庫鏈接：

KEGG: dme:Dmel_CG12193

STRING: 7227.FBpp0077541

UniGene: Dm.19764