HEK293T/Mouse CDCP1 Stable Cell Line

貨號：

CSB-SC719456MO1
規(guī)格：

1 vial contains approximately 5x10⁶ cells in 1 ml
價格：

￥30000
活性：
Untransfected HEK293T cells (green line) and transfected Mouse Cdcp1 HEK293T stable cells (red line) were stained with anti-CDCP1 antibody (2μg/1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
其他：

產(chǎn)品詳情

Uniprot No.：

Q5U462
生長類型：

Adherent
抗性：

Puromycin
培養(yǎng)基：

DMEM + 10% FBS + 2 μg/ml Puromycin
別名：

CDCP1
蛋白標(biāo)簽：

N-terminal Flag-tagged
保存緩沖液：

35% FBS + 55% DMEM + 10% DMSO
應(yīng)用范圍：

Binding assay by FACS and cell based ELISA.
儲存條件：

Frozen in liquid nitrogen or -80°C
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

功能：

May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
基因功能參考文獻：
1. Results indicate Cdcp1 (CD318) as a ligand of T-cell differentiation antigen CD6 (CD6) and a potential target for the diagnosis and treatment of autoimmune diseases. PMID: 28760953
2. Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells. PMID: 23243018
3. established mechanism for initiation of CDCP1-mediated signaling; demonstrated that processing of surface CDCP1 by extracellular serine proteases is prerequisite for CDCP1-dependent survival of cancer cells during metastasis; preventing cleavage of CDCP1 abrogated survival signaling associated with CDCP1 and induced PARP1 cleavage and PARP1-mediated apoptosis PMID: 22179830
4. CDCP1 may have a role in neoplasm metastasis; targeting it with a monoclonal antibody inhibits metastasis in a prostate cancer model PMID: 18483259
亞細胞定位：

Cell membrane; Single-pass membrane protein.
數(shù)據(jù)庫鏈接：

KEGG: mmu:109332

STRING: 10090.ENSMUSP00000042057

UniGene: Mm.27519

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