Recombinant Schizosaccharomyces pombe Tethering factor for nuclear proteasome cut8 (cut8)

中文名稱：

Recombinant Schizosaccharomyces pombe Tethering factor for nuclear proteasome cut8(cut8)
貨號：

CSB-YP340030SXV
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Schizosaccharomyces pombe Tethering factor for nuclear proteasome cut8(cut8)
貨號：

CSB-EP340030SXV
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Schizosaccharomyces pombe Tethering factor for nuclear proteasome cut8(cut8)
貨號：

CSB-EP340030SXV-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Schizosaccharomyces pombe Tethering factor for nuclear proteasome cut8(cut8)
貨號：

CSB-BP340030SXV
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Schizosaccharomyces pombe Tethering factor for nuclear proteasome cut8(cut8)
貨號：

CSB-MP340030SXV
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

cut8
Uniprot No.：

P38937
別名：

cut8; SPAC17C9.13cTethering factor for nuclear proteasome cut8; Cell untimely torn protein 8
種屬：

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
蛋白長度：

full length protein
表達區域：

1-262
氨基酸序列

METLSYSQIK KRKADFDEDI SKRARQLPVG EQLPLSRLLQ YSDKQQLFTI LLQCVEKHPD LARDIRGILP APSMDTCVET LRKLLINLND SFPYGGDKRG DYAFNRIREK YMAVLHALND MVPCYLPPYS TCFEKNITFL DAATNVVHEL PEFHNPNHNV YKSQAYYELT GAWLVVLRQL EDRPVVPLLP LEELEEHNKT SQNRMEEALN YLKQLQKNEP LVHERSHTFQ QTNPQNNFHR HTNSMNIGND NGMGWHSMHQ YI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Together with nucleoporin alm1, tethers the proteasome to the nuclear envelope. Involved in ubiquitin-mediated protein degradation and facilitates the degradation of nuclear proteins like mitotic cyclin and cut2. Required for normal progression of anaphase.
基因功能參考文獻：
1. A loss of the cut8(+) gene encoding an anchor of the proteasome to the nuclear membrane causes disruption in CENP-A distribution. PMID: 24710126
2. Cut8 contains a unique, modular fold composed of an extended N-terminal, lysine-rich segment that when ubiquitinated binds the proteasome, a dimer domain followed by a six-helix bundle connected to a flexible C tail. PMID: 21976488
3. Cut8 is required for the repair of DNA double-strand breaks, ribosomal DNA maintenance, and cell survival in the absence of Rqh1 helicase. PMID: 17178839
亞細胞定位：

Nucleus envelope.
蛋白家族：

Cut8/STS1 family
數據庫鏈接：

KEGG: spo:SPAC17C9.13c

STRING: 4896.SPAC17C9.13c.1