Recombinant Rat Xanthine dehydrogenase/oxidase (Xdh), partial

中文名稱：

大鼠Xdh重組蛋白
貨號：

CSB-YP026189RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Xdh重組蛋白
貨號：

CSB-EP026189RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Xdh重組蛋白
貨號：

CSB-EP026189RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Xdh重組蛋白
貨號：

CSB-BP026189RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Xdh重組蛋白
貨號：

CSB-MP026189RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Xdh
Uniprot No.：

P22985
別名：

Xdh; Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase; XD; EC 1.17.1.4); Xanthine oxidase; XO; EC 1.17.3.2; Xanthine oxidoreductase; XOR)]
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
基因功能參考文獻：
1. S-allyl cysteine as potent anti-gout drug: Insight into the xanthine oxidase inhibition and anti-inflammatory activity. PMID: 30059711
2. Abdominal paracentesis drainage protects rats against severe acute pancreatitis-associated lung injury by reducing the mobilization of intestinal xanthine dehydrogenase. PMID: 27585949
3. Our results show that XOR is important to the cardiovascular responses to nitrite in 2K1C hypertension, and XOR inhibitors commonly used by patients may cancel this effect. This finding suggests that nitrite treatment may not be effective in patients being treated with XOR inhibitors PMID: 27078869
4. Hepatocyte growth factor prevents XO activation following hypoxia/reoxygenation primarily by inhibiting the JAK2 signaling pathway and in turn, inhibiting the increase in cytosolic Calcium. PMID: 27573711
5. Treatment with etaftorone decreased expression of inducible NOS and XOR in kidneys, whereas it increased the expression of endothelial NOS. PMID: 26663724
6. Results suggest that exaggerated XO activity and resultant increase in oxidative stress contributes to hypertension and xanthine oxidase inhibition could treat treating hypertension and related endothelial dysfunction. PMID: 27198514
7. Transitional cell tumors induced by xanthine oxidase inhibitor topiroxostat in rats were due to physical stimulation to transitional cells of xanthine crystals/calculi. PMID: 24448833
8. metabolism of sodium metabisulfite in liver tissue increased XO activity, induced ER stress and caused caspase activation which was attenuated by ghrelin treatment PMID: 25486021
9. We have constructed a variant of the liver enzyme that lacks the carboxy-terminal amino acids 1316-1331; it appears to assume an intermediate form, exhibiting a mixture of dehydrogenase and oxidase activities. PMID: 25817260
10. Data suggest that, with aging, up-regulation of reactive oxygen species derived from XO down-regulates uric acid excretion via down-regulation of active homodimer breast cancer resistance protein (Bcrp1, uric acid efflux transporter) in ileal mucosa. PMID: 26119820
11. Rat Xdh is a moonlighting protein that has two distinct catalytic activities as a dehydrogenase and an oxidase. PMID: 15878860
12. Allopurinol improves left ventricular contractile function and efficiency possibly by diminishing the known XO-mediated ROS effects on myofilament Ca(2+) sensitivity. PMID: 24014679
13. crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase and of the reduced bovine milk enzyme PMID: 21077683
14. 6-mercaptopurine treatment resulted in increased xanthine oxidase (Xdh) expression in the placenta. PMID: 22688000
15. The present study indicates that enhancement of XO activity could be implicated in acrylonitrile-induced gastric damage in rats. PMID: 22648241
16. inhibition ameliorates sympathetic innervation and arrhythmias PMID: 21295134
17. Report differential effects of xanthine oxidase inhibition and exercise on albumin concentration in rat tissues. PMID: 20555367
18. Xanthine oxidase inhibition can offer protection from radiation-induced endothelial dysfunction and cardiovascular complications. PMID: 20167676
19. xanthine oxidase and nitric oxide synthase have a role in cocaine-induced oxidative damage to skin PMID: 20399619
20. Aluminium increases xanthine oxidase activity and disturbs antioxidant status in the rat. PMID: 11787993
21. a pivotal role in cytokine-induced bone resorption PMID: 12653206
22. Contractile claudication causes an increase in xanthine oxidase activity in muscles. Inhibition of these oxidant sources protects against oxidative stress, muscle damage, and edema. PMID: 12969896
23. 17alpha- and 17beta-estradiol modulate the hypoxia-induced regulation of XDH/XO activity at a posttranscriptional level by a receptor-independent mechanism PMID: 14588143
24. role for locally synthesized XOR in the development of hypertension-associated end-organ damage, but no major role in the development of hypertension. PMID: 15201549
25. Major part of reactive oxygen species (ROS) generation in acute rejection was contributed by xanthine oxidoreductase(XOR). ROS are associated with and contribute to acute allograft rejection because inhibition of XOR alleviated rejection phenomena. PMID: 15201667
26. analysis of cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant PMID: 15878860
27. RONS formation by xanthine oxidase prevents activation of important signalling pathways, predominantly the MAPK-NF-kappaB pathway PMID: 15932896
28. Nitrite-derived nitric oxide by xanthine oxidoreductase in hypoxic and acidic environment induced by hepatic ischemia reperfusion injury(I/R) protects liver against I/R injury in vivo. PMID: 16109514
29. results point to an important role for xanthine oxidase in the early stage of hyperlipidemia-associated renal injury, mediating macrophage infiltration by a putatively redox-dependent upregulation of MCP-1 and VCAM-1 PMID: 16407880
30. increased free radical generation-associated increase in SBP in aging rats is xanthine oxidase but not NAD(P)H oxidase-dependent PMID: 17031261
31. Study presents a mutant of rat XOR that displays mainly XO activity with a superoxide:hydrogen peroxide production ratio of about 6:1. PMID: 17301076
32. the NADH oxidase activity of both xanthine dehydrogenase (XD) and xanthine oxidase (XO) forms of rat liver xanthine oxidoreductase (XOR) and the potential role of this mammalian enzyme as an O2*- source PMID: 17440754
33. data provide the first evidence indicating that the JAK-STAT pathway is involved in hypoxia-mediated xanthine dehydrogenase/oxidase (XDH/XO) activation in lung microvascular endothelial cells PMID: 17920330
34. Hypoxia-exposed pups had evidence of increased serum and lung XO activity, increased vascular XO-derived superoxide production, and vascular nitrotyrosine formation. PMID: 18083771
35. Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. PMID: 18487445
36. Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. PMID: 18818408
37. Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction. PMID: 18974366
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亞細胞定位：

Peroxisome. Cytoplasm. Secreted.
蛋白家族：

Xanthine dehydrogenase family
數據庫鏈接：

KEGG: rno:497811

STRING: 10116.ENSRNOP00000009634

UniGene: Rn.202951