Recombinant Rat Ubiquitin-like protein ATG12 (Atg12)

中文名稱：

Recombinant Rat Ubiquitin-like protein ATG12(Atg12)
貨號：

CSB-YP651912RA
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Ubiquitin-like protein ATG12(Atg12)
貨號：

CSB-EP651912RA
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Ubiquitin-like protein ATG12(Atg12)
貨號：

CSB-EP651912RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Ubiquitin-like protein ATG12(Atg12)
貨號：

CSB-BP651912RA
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Ubiquitin-like protein ATG12(Atg12)
貨號：

CSB-MP651912RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Atg12
Uniprot No.：

Q2TBJ5
別名：

Atg12; Apg12lUbiquitin-like protein ATG12; Autophagy-related protein 12; APG12-like
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-141
氨基酸序列

MAEDPEAVLQ LPAAPAAAAG ESLLELSPET AIPEPPSSVA VSPGTEEPPG DTKKKIDILL KAVGDTPIMK TKKWAVERTR TVQALIDFIR KFLRLLASEQ LFIYVNQSFA PSPDQEVGTL YECFGSDGKL VLHYCKSQAW G
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
基因功能參考文獻：
1. Study demonstrated that miR-23b expression was significantly downregulated following traumatic brain injury (TBI). In model TBI, overexpression of miR-23b reduced the lesion volume, brain edema and neuronal apoptosis, and improves cognitive dysfunction. miR-23b specifically bound with the 3' UTR of ATG12 mRNA and modulated its translation; suppressed neuronal autophagy by directly targeting ATG12 expression. PMID: 27630106
亞細胞定位：

Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
蛋白家族：

ATG12 family
數據庫鏈接：

KEGG: rno:361321

STRING: 10116.ENSRNOP00000000170

UniGene: Rn.6224