Recombinant Rat Solute carrier family 2, facilitated glucose transporter member 1 (Slc2a1), partial

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中文名稱：

大鼠Slc2a1重組蛋白
品名簡稱：

Recombinant Rat Slc2a1 protein, partial
貨號：

CSB-EP319259RA
說明書：

MSDS Datasheet
規格：

￥2328
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Slc2a1
Uniprot No.：

P11167
別名：

(Glucose transporter type 1, erythrocyte/brain)(GLUT-1)
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
來源：

E.coli
分子量：

15.2 kDa
表達區域：

207-271aa
氨基酸序列

CPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged and C-terminal Myc-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors.
基因功能參考文獻：
1. Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming PMID: 26590355
2. The data of this study provided evidence that histone deacetylation may contribute toward the loss of GLT-1 PMID: 26953753
3. Increased GLUT1 expression was observed together with overproduction of NO and pronounced liver injury in severely hyperglycaemic rats. GLUT1 overexpression might be implicated in the toxic effects of glucose in the liver. PMID: 26347179
4. The GLUT1 plays a role in regulation of ROS and could contribute to maintenance of insulin action in the presence of ROS. PMID: 25101238
5. In the cerebral cortex, GLUT1 increased at 18 h postexercise. PMID: 24610532
6. Ezrin is down-regulated in diabetic kidney glomeruli and regulates actin reorganization and glucose uptake via GLUT1 PMID: 24726496
7. Ascorbic acid markedly upregulated the basal expression of GLUT1 in endothelial cells of nondiabetic and diabetic cortex, which did not affect total ascorbic acid levels in the cortex. PMID: 24739976
8. Hypothalamic GLUT1 mRNA abundance increases with age and is sexually dimorphic PMID: 24382486
9. The expression of glut1 and glut4 in brain areas was not down-regulated, however, we observed trend to phase advance in glut1 expression in the cerebellum. PMID: 24329691
10. The aim of the work was to evaluate GLUT1 and GLUT2 in kidneys of an animal model of metabolic syndrome. PMID: 24062089
11. GLUT1 content is reduced in kidney cortex in diabetic hypertensive rats after blockade of the renin-angiotensin system, a phenomenon not specifically related to decreased blood pressure levels. PMID: 23680377
12. The Akt/TSC/mTOR/S6K signaling pathway may be one of the mechanisms underlying the upregulation of GLUT1 expression in uremic vascular smooth muscle cells. PMID: 23265586
13. CoCl(2) can increase mRNA expressions of GLUT1 and GLUT3 and glucose transporter activity of neurons in hypoxic conditions. PMID: 12506324
14. that n-3 deficiency repressed GLUT1 gene expression in the cerebral cortex PMID: 22579067
15. Progesterone could increase the tolerance of neurons to hypoxic-ischemia by up-regulating GLUT1 and GLUT3 expression. PMID: 21141602
16. We found that although cocaine withdrawal decreases GLT1 expression in both core and shell of the nucleus accumbens, only in core is GLT1 downregulation sensitive to both access and withdrawal PMID: 22433294
17. Data suggest that triiodothyronine (T3) up-regulates Glut1 and Glut3 in osteoblasts; thus, increased glucose uptake induced by T3 may be mediated by these high-affinity glucose transporters. PMID: 22258767
18. The expression of GLUT4 was lower in older animals, but no relation between age and GLUT1 expression was found. PMID: 22125125
19. During status epilepticus GLUT1 expression is increased throughout the brain between 1 and 12 hours, occurring more strongly in adult rats. PMID: 21624469
20. GLUT1 enhances mTOR activity independently of TSC2 and AMPK. PMID: 21613414
21. GLUT1 expression was statistically unchanged on the ketogenic diet. PMID: 21605500
22. Sustained hyperglycemia impairs hypothalamic glucose sensing to lower glucose production through changes in hypothalamic glial GLUT1. Data highlight the critical role of hypothalamic glial GLUT1 in mediating glucose sensing to regulate glucose production. PMID: 21562080
23. Results indicate that CHAs(OH) and water use a common translocation pathway in GLUT1 that is different to that of glucose transport. PMID: 21069159
24. Increased podocyte GLUT1 expression in diabetic mice does not contribute to early diabetic nephropathy. It protects against mesangial expansion and fibronectin accumulation possibly by blunting podocyte VEGF increases. PMID: 20375116
25. The mRNA and protein expression of GLUT1 in brain tissue increased significantly after hypoxic-ischemia. PMID: 19950593
26. GLUT1 and GLUT3 expression was notably up-regulated in the penumbra region after cerebral ischemia. PMID: 19781384
27. gene expression regulation by Sp1 in differentiating trophoblasts PMID: 11689000
28. Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation PMID: 11738800
29. abundant in the occludin-positive endothelial cells of the nasal olfactory mucosa PMID: 11751462
30. Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element. PMID: 11906001
31. Glut1 is localized in astrocytic processes around axonal or dendritic elements of glutamatergic axo-dendritic synaptic junctions in the frontoparietal somatosensory cortex. PMID: 11950769
32. Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidyl-inositol-3-kinase pathway in the rat heart. PMID: 12002265
33. Glucose transport was associated with enhanced accessibility of GLUT1 to its substrate and with photolabelling of formerly 'cryptic' exofacial substrate binding sites in GLUT1 molecules. PMID: 12006627
34. Gene expression in the jejunum in response to insulin-like growth factors in rat pups. PMID: 12388463
35. GLUT1 protein localised to the cytoplasm and basolateral surface of mammary epithelial cells in lactating rats PMID: 12483288
36. Insulin-induced translocation of facilitative glucose transporters in fetal/neonatal rat skeletal muscle PMID: 12531786
37. Upregulation of GLUT-1 expression: Link between hemodynamic and metabolic factors in glomerular hypertension? PMID: 12771048
38. upregulation of GLUT1 serves a role in agonist-induced hypertrophy and survival which can be dissociated from its role in glucose transport PMID: 14519432
39. A close correlation was found between local MCT1 and local GLUT1 densities. As local GLUT1 densities reflect local glucose metabolism in the brain, we conclude that local MCT1 densities are adjusted to local glucose metabolism and transport. PMID: 14729246
40. Glucose uptake by way of 2-deoxyglucose and GLUT-1 transporter protein content was measured in basal and insulin-stimulated skeletal muscle cells. PMID: 14741039
41. TATA box in the promoter of the GLUT1 gene is required by the agonist to activate transcription from the promoter. PMID: 15808844
42. GLUT1 and GLUT8 are both expressed in prepubertal testis, but only GLUT1 is regulated by l-triiodothyronine (T(3)); also found that the effect of T(3) cannot be attributed to its action on GLUT1 promoter PMID: 15811071
43. The impact on urinary TGF-beta1 occurs when diabetes and hypertension are associated, suggesting an effect that is triggered in the presence of GLUT1 overexpression and hyperglycemia. PMID: 15855808
44. Levels of both GLUT1 and GLUT12 are elevated in animal models of hypertension and diabetic nephropathy. PMID: 16091581
45. Decreased glucose utilization in the cerebral cortex of (n-3) PUFA-deficient rats is due to reduced amounts of the 2 isoforms of GLUT1, indicating post-transcriptional regulation of GLUT1 synthesis. PMID: 16140905
46. Data show that the consensus Sp1 site located in the rat proximal glucose transporter (Glut)1 promoter is necessary and sufficient for basal expression of the Glut1 gene, as well as for its response to hyperosmolarity. PMID: 16162661
47. Findings suggest the presence of GLUT1 in detergent-resistant membrane domains of spermatogenic cells, and support a role for caveolae in relation to glucose uptake and glucose phosphorylation. PMID: 16419038
48. susceptibility to diabetic glomerulopathy in MNS rats is associated with increased GLUT1-dependent glucose transport activity in response to hyperglycaemia and/or TGF-beta, which may amplify ECM overproduction. PMID: 16449286
49. results indicate that AQP4 may play a much more important role in blood-brain barrier function than GLUT-1, and thereby also in water distribution in the cerebral cortex of stroke-prone spontaneously hypertensive rats with severe hypertension PMID: 16461188
50. the regulation of GLUT1 and GLUT3 in cerebral cortex is regulated by T(3)and the expression of glucose transporters induced by hypothyroidism might have a functional impact on brain glucose uptake. PMID: 16581179
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Photoreceptor inner segment.
蛋白家族：

Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
組織特異性：

Detected in osteoblastic cells (at protein level). Detected in brain, and at lower levels in kidney, heart and lung.
數據庫鏈接：

KEGG: rno:24778

STRING: 10116.ENSRNOP00000061340

UniGene: Rn.3205