Recombinant Rat Sodium channel protein type 8 subunit alpha (Scn8a), partial

中文名稱：

大鼠Scn8a重組蛋白
貨號：

CSB-YP020845RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Scn8a重組蛋白
貨號：

CSB-EP020845RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Scn8a重組蛋白
貨號：

CSB-EP020845RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Scn8a重組蛋白
貨號：

CSB-BP020845RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Scn8a重組蛋白
貨號：

CSB-MP020845RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Scn8a
Uniprot No.：

O88420
別名：

Scn8a; Sodium channel protein type 8 subunit alpha; Peripheral nerve protein type 4; PN4; Sodium channel 6; NaCh6; Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
基因功能參考文獻：
1. To clarify the exact expression patterns of Nav1.6 during epileptogenesis, we examined the expression of Nav1.6 at protein and mRNA levels in two distinct models of temporal lobe epilepsy including a post-status epilepticus model induced by kainic acid intrahippocampal injection and a kindling model evoked by pentylenetetrazole. PMID: 27905510
2. Data strongly suggest that voltage-gated sodium channel subunit alpha Nav1.6 ( Nav1.6) plays an indispensable role in the peripheral pain hypersensitivity induced by BmK I. PMID: 28655185
3. Study provides insight into the dynamics of Nav1.6 on the cell surface and raises new questions such as how somatic localization and function are linked and how localized regulation of these channels may influence overall neuronal physiology. PMID: 27653482
4. The data support a model where ankyrinG-binding is required for preferential Nav1.6 insertion into the axon initial segment plasma membrane during development. PMID: 25874799
5. Results highlight the relative importance of abnormal sensory neuron spontaneous activity in establishing both pain behaviors and sympathetic sprouting, and suggest that the NaV1.6 isoform may have value as a therapeutic target PMID: 25686526
6. This study demonistrated that Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia in rats. PMID: 23622763
7. inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons. PMID: 23640885
8. Deltamethrin and tefluthrin (but not S-bioallethrin) bind to Na(v)1.6Q3 channels in the open state and imply that the pyrethroid receptor of resting and open channels occupies different conformations that exhibit distinct structure-activity relationships. PMID: 22465659
9. Data demonstrate that the two N-terminal alternatively spliced FGF14 variants, FGF14-1a and FGF14-1b, differentially regulate currents produced by Nav1.2 and Nav1.6 channels. PMID: 19465131
10. These results identify unique effects of the beta1 and beta2 subunits and demonstrate that joint modulation by both auxiliary subunits gives Nav1.6 properties that are not predicted by the effects of individual subunits. PMID: 21439942
11. study revealed presence of the Nav1.6 subunit in hippocampal CA1 pyramidal cell proximal & distal dendrites; results reveal characteristic subcellular distribution of the Nav1.6 subunit, identifying it as a key substrate enabling dendritic excitability PMID: 20466935
12. FHF2 is abundantly expressed in the hippocampus and DRG neurons and colocalizes with Na(v)1.6 at mature nodes of Ranvier in myelinated sensory fibers in the dorsal root of the sciatic nerve. PMID: 15282281
13. Nav1.6 and p38 are colocalized in rat cerebellar Purkinje neurons suggesting the possibility that p38 can phosphorylate the channel in vivo. PMID: 16014723
14. Nav1.1 and Nav1.6 are the dominant subunits in the sinoatrial node (SAN), and downregulation of Nav1.1 and Nav1.6 expression contributes to heart failure-induced SAN dysfunction. PMID: 17273863
15. The changes identified in this study suggest that the participation of Nav1.6 should be considered when examining changes in the excitability of myelinated axons in neuropathic pain models. PMID: 17662136
16. both SCN8A and ankyrin-G increased significantly in the CA1 subfield of the rat hippocampus 60 days following pilocarpine induced status epilepticus and co-localized with each other PMID: 19306853
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell projection, axon.
蛋白家族：

Sodium channel (TC 1.A.1.10) family, Nav1.6/SCN8A subfamily
組織特異性：

Isoform 1 is highly expressed in brain, moderately in spinal cord, and at low levels in dorsal root ganglia, nodose ganglia and superior cervical ganglia. Not detected in sciatic nerve and non-neuronal tissues. Isoform 2 is hardly detectable, if at all, i
數據庫鏈接：

KEGG: rno:29710

STRING: 10116.ENSRNOP00000008160

UniGene: Rn.91216