Recombinant Rat Sodium/calcium exchanger 3 (Slc8a3), partial

中文名稱：

大鼠Slc8a3重組蛋白
貨號：

CSB-YP021725RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Slc8a3重組蛋白
貨號：

CSB-EP021725RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Slc8a3重組蛋白
貨號：

CSB-EP021725RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Slc8a3重組蛋白
貨號：

CSB-BP021725RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Slc8a3重組蛋白
貨號：

CSB-MP021725RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc8a3
Uniprot No.：

P70549
別名：

Slc8a3; Ncx3; Sodium/calcium exchanger 3; Na(+)/Ca(2+)-exchange protein 3; Solute carrier family 8 member 3
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis.
基因功能參考文獻：
1. This cardioprotective effect was potentially achieved via up-regulating p-AKT and SLC8A3. PMID: 29763795
2. There is a significant reduction in NCX3 expression in rats with febrile convulsions. PMID: 26608990
3. This study demonstrated that the change in NCX3 in the cell body was associated with a decrease in NCX3 protein in the ganglia, an increase in the peripheral nerve (sciatic) yet no change in the central root. PMID: 26041911
4. This study showed that normobaric hyperoxia changes the patterns of NCXs expression in the brain; up-regulates the expression of NCX3 in the in the spinal cord cord, penumbra and subcortex. PMID: 23403180
5. NCX3 in reverse mode was found to be another influx route for increasing [Ca2+]i, which might be involved in interstitial cells of Cajal-like cell excitability. PMID: 23688374
6. High levels of NCX3 overexpression increase neuronal survival following hypoxia-ischemia and improve neuronal calcium management. PMID: 22561287
7. calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation. PMID: 21959935
8. NCX3/Slc8a3, a Na(+)/Ca(2+) membrane exchanger, is highly expressed in astrocytes, both in vitro and in vivo, in response to glutamate-induced excitotoxicity. PMID: 20928830
9. NCX3 silencing, induced by intracerebroventricular infusion of small interfering RNA (siRNA), partially reverted postconditioning-induced neuroprotection PMID: 20628398
10. Brain ischemia regulates gene expression levels of Na+/Ca2+ exchanger isoform NCX3, especially in cerebral cortex. PMID: 12377375
11. NCX3 mRNAs were detected in the hippocampus, thalamus, amygdala, and cerebellum. The NCX3 protein was found in the specific subregions of the hippocampus, the ventral striatum, and in the cerebellar molecular layer. PMID: 12722103
12. Proteolytic inactivation of NCX-driven neuronal Ca2+ extrusion is responsible for the delayed excitotoxic Ca2+ deregulation and neuronal death. PMID: 15680332
13. Expression is depressed in heart failure. PMID: 15681692
14. Slc8a3 constitutes a novel additional target for the prosurvival action of Akt/protein kinase B pathway. PMID: 18079274
15. NCX3 protein is proposed as a distress signal able to modulate intraneuronal homeostasis of sodium and divalent calcium ions whenever neurons undergo severe anoxia. PMID: 18234895
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Cell membrane, sarcolemma. Cytoplasm, sarcoplasm. Cell junction. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region.
蛋白家族：

Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC8 subfamily
組織特異性：

Detected in neurons in brain cortex and hippocampus. Detected in pyramidal cell bodies and processes, in granule cells and interneurons in the CA1 and CA3 region of the hippocampus. Detected on astrocyte processes in brain cortex. Detected on endothelial
數據庫鏈接：

KEGG: rno:140448

STRING: 10116.ENSRNOP00000041987