Recombinant Rat Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (Pip5k1b)

中文名稱：

大鼠Pip5k1b重組蛋白
貨號：

CSB-YP685613RA
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Pip5k1b重組蛋白
貨號：

CSB-EP685613RA
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Pip5k1b重組蛋白
貨號：

CSB-EP685613RA-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Pip5k1b重組蛋白
貨號：

CSB-BP685613RA
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Pip5k1b重組蛋白
貨號：

CSB-MP685613RA
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pip5k1b
Uniprot No.：

Q5CZZ9
別名：

Pip5k1b; Pip5k1a; Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; PIP5K1-beta; PtdIns(4)P-5-kinase 1 beta; EC 2.7.1.68; Phosphatidylinositol 4-phosphate 5-kinase type I alpha; PIP5KIalpha; Phosphatidylinositol 4-phosphate 5-kinase type I beta; PIP5KIbeta
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-539
氨基酸序列

MSSTAENGDA VPGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER DVLMQDFYVV ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI KPDDYLYSIC SEPLIELSNP GASGSLFFLT SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG INIRIVVMNN VLPRAMRMHL TYDLKGSTYK RRASRKEREK PNPTFKDLDF LQDMHEGLYF DTETYNALMK TLQRDCRVLE SFKIMDYSLL LGIHILDHSL KDKEEEPLQN APDAKRPGMQ KVLYSTAMES IQGPGKSADG IIAENPDTMG GIPAKSHKGE KLLLFMGIID ILQSYRLMKK LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ ALKASPSKKR CNSIAALKAT SQEILSSISQ EWKDEKQDLL TEGQSFSSLD EEALGSRHRP DLVPSTPSLF EAASLATTIS SSSLYVGEHY PHDRTTLYSN SKGLPSSSTF TLEEGTIYLT AEPNALETQD DASVLDVYL
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion.
基因功能參考文獻(xiàn)：
1. PIP5Kalpha acts as a negative regulator of nerve growth factor-induced neurite outgrowth by inhibiting PI3K/Akt signaling pathway in PC12 cells. PMID: 23538529
2. Ganglioside treatment of primary astrocytes enhances PIP5Kalpha expression. PIP5Kalpha knockdown attenuates ganglioside-induced inflammatory responses. PMID: 20720456
3. The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells. PMID: 19549683
亞細(xì)胞定位：

Cytoplasm, cytosol. Cell membrane. Endomembrane system.
數(shù)據(jù)庫鏈接：

KEGG: rno:309419

STRING: 10116.ENSRNOP00000063506

UniGene: Rn.203303