Recombinant Rat Melanoma-associated antigen D1 (Maged1)

中文名稱：

大鼠Maged1重組蛋白
貨號：

CSB-YP866840RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Maged1重組蛋白
貨號：

CSB-EP866840RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Maged1重組蛋白
貨號：

CSB-EP866840RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Maged1重組蛋白
貨號：

CSB-BP866840RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Maged1重組蛋白
貨號：

CSB-MP866840RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Maged1
Uniprot No.：

Q9ES73
別名：

Maged1; Nrage; Melanoma-associated antigen D1; MAGE-D1 antigen; Neurotrophin receptor-interacting MAGE homolog; Sertoli cell necdin-related gene protein 1; SNERG-1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-775
氨基酸序列

MAQKPDGGAG LRGFQAEASV EDSALLVQTL MEAIQISEAP PTSQATAAAS GPNASPQSSQ PPTANEKADT EVSAAAARPK TGFKAQNTTT KGPNDYSQAR NAKEMPKNQP KVAFKSQNAT SKGPHAASDF SHAASTGKSA AKKSEMAFKG QNTTTKAGPS ATYNFTQSPS ANEMTNNQPK TAKAWNDTTK IPGADAQTQN VNQAKMADVG TSAGISETDG AAAQTSADGS QAQNVESRTI IRGKRTRKIN NLNVEENSNG DQRRASLASG NWRSAPVPVT TQNPPGAPPN VLWQTPLAWQ NPSGWQNQTA RQTPPARQSP PARQTPSAWQ NPVAWQNPVI WPNPVIWQNP VIWPNPIVWP GPIVWPNPMA WQSTPGWQSP PSWQAPPSWQ SPQDWQGPPD WQLPPDWSMP PDWSFPSDWP FPPDWIPADW PIPPDWQNLR PSPNLRSSPN SRASQNQGPP QPRDVALLQE RANKLVKYLM LKDYTKVPIK RSEMLRDIIR EYTDVYPEII ERACFVLEKK FGIQLKEIDK EEHLYILIST PESLAGILGT TKDTPKLGLL LVILGIIFMN GNRATEAVLW EALRKMGLRP GVRHPLLGDL RKLLTYEFVK QKYLDYRRVP NSNPPEYEFL WGLRSYHETS KMKVLRFIAE VQKRDPRDWT AQFMEAADEA LDALDAAAAE AEARAEARNR MGIGDEAVSG PWSWDDIEFE LLTWDEEGDF GDPWSRIPFT FWARYHQNAR SRFPQAFTGP IIGPSGTATA NFAANFGAIG FFWVE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
基因功能參考文獻：
1. Praja1, through ubiquitination and degradation of NRAGE, inhibits neuronal differentiation. PMID: 23717400
2. effects on neuritogenesis are promoted through interactions of Dlxin-1 with the neurotrophin receptor TrkA PMID: 20595047
3. identification of NRAGE as a p75NTR interactor capable of inducing caspase activation and cell death through a JNK-dependent mitochondrial apoptotic pathway PMID: 12376548
4. The results are consistent with an important role for NRAGE in p75(NTR) signaling, as all cells that expressed p75(NTR) also expressed NRAGE. The wider distribution of NRAGE expression suggests that NRAGE may also participate in other signaling processes. PMID: 15878242
亞細胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
組織特異性：

Ubiquitous and in the seminiferous tubules expressed in Sertoli cells but not in germ cells. Expression decreases in all tissues with increased age and is detectable only in brain cortex and lung.
數據庫鏈接：

KEGG: rno:84469

STRING: 10116.ENSRNOP00000009870

UniGene: Rn.54596