Recombinant Rat M-phase inducer phosphatase 1 (Cdc25a)

中文名稱：

Recombinant Rat M-phase inducer phosphatase 1(Cdc25a)
貨號：

CSB-YP004994RA
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat M-phase inducer phosphatase 1(Cdc25a)
貨號：

CSB-EP004994RA
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat M-phase inducer phosphatase 1(Cdc25a)
貨號：

CSB-EP004994RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat M-phase inducer phosphatase 1(Cdc25a)
貨號：

CSB-BP004994RA
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat M-phase inducer phosphatase 1(Cdc25a)
貨號：

CSB-MP004994RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cdc25a
Uniprot No.：

P48965
別名：

Cdc25a; M-phase inducer phosphatase 1; EC 3.1.3.48; Dual specificity phosphatase Cdc25A
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-525
氨基酸序列

MELGPEPPHR RRLLFTCSPT PAPQPTGKVQ FGASRAGGLS PVTNLTVTMD QLEGLGSDYE KPMDVRNSSS LQRMGSSEST DSGFCLDSPG PLDSKENLEI SLRRINCLPQ KLLGCSPALK RSHSDSLDHD IFQLIDQDEN KENEAFEFKK PIRPASRGCL NAHVHEESKD PFTHRQNSAP ARMLSSNESD ISESGNFSPL FTPQSPVKAS LSDEDDGFID LLDGENLKND EETPSCMSSL WTAPLVMRRP TNLADRCGLF DSPSPCSSTS SCSTRAVKRA DRSHEESPRG TKRRKSSEAS PVKADVPEPT QLPHQSLSLT SFPKGTIENI FHSDPRDLIG DFSKGYLFHT VSGKHQDLKY ISPEIMASVL NGKFANLIKE FVIIDCRYPY EYEGGHIKGA VNLHMEEEVE EFLLKKPIVP ADGKRVIVVF HCEFSSERGP RMCRYVRERD RLGNEYPKLH YPELYVLKGG YKEFFLKCQS HCEPPSYRPM HHEDFKEDLK KFRTKSRTWA GEKSKREMYS RLKKL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro. Phosphorylation by PIM1 leads to an increase in phosphatase activity.
基因功能參考文獻：
1. accelerated cholangiocyte cystogenesis is likely due to overexpression of Cdc25A PMID: 24211536
2. Cdc25A inhibitors block cell-cycle progression and proliferation, reduce liver and kidney weights and cyst growth in animal models of polycystic kidney/liver disease. PMID: 22155366
3. 1,25(OH)(2)D inhibits VSMC proliferation through a Cdc25A-dependent mechanism and suggest that this hormone may prove useful in the management of disorders characterized by aberrant proliferation of VSMC in the vascular wall. PMID: 20813185
4. endothelin increases expression and activity of CDC25A, the regulatory phosphatase responsible for dephosphorylating Tyr(15). PMID: 14742443
5. MicroRNA15a modulates expression of Cdc25a and affects hepatic cystogenesis in a rat model of polycystic kidney disease. PMID: 18949056
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蛋白家族：

MPI phosphatase family
數據庫鏈接：

KEGG: rno:171102

STRING: 10116.ENSRNOP00000028141

UniGene: Rn.11390