Recombinant Rat Hephaestin (Heph), partial

中文名稱：

大鼠Heph重組蛋白
貨號：

CSB-YP010289RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Heph重組蛋白
貨號：

CSB-EP010289RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Heph重組蛋白
貨號：

CSB-EP010289RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Heph重組蛋白
貨號：

CSB-BP010289RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Heph重組蛋白
貨號：

CSB-MP010289RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Heph
Uniprot No.：

Q920H8
別名：

Heph; Hephaestin; EC 1.-.-.-
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.
基因功能參考文獻：
1. Cytosolic Heph increased upon iron-deprivation but more important, decreased significantly upon copper-deprivation, mimicking the response of membrane-bound Heph. PMID: 22350470
2. Reduced interactions between Fpn and Heph after iron ingestion indicate that this is a regulatory mechanism for limiting further iron absorption. PMID: 21473866
3. Results suggest that FPN1 and/or HP might directly contribute to iron efflux process from neurons in conditions of overexpression, thus prevent cellular iron accumulation and eventually protect cells from iron-induced oxidative stress. PMID: 20564203
4. Hephaestin might have a role in heart iron homeostasis. PMID: 17383861
5. Development and iron-dependent expression of Heph in different brain regions is reported. PMID: 17516501
6. These results show for the first time that FP1 and HP co-localize in the rat brain, and suggest that decreased expression of these transporters in the SN can account for the increased iron levels. PMID: 17561842
7. Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium. PMID: 18974313
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Multicopper oxidase family
組織特異性：

Highly expressed in small intestine and colon.
數據庫鏈接：

KEGG: rno:117240

STRING: 10116.ENSRNOP00000017312

UniGene: Rn.43849