Recombinant Rat Cyclin-dependent kinase 4 inhibitor B (Cdkn2b)

中文名稱：

Recombinant Rat Cyclin-dependent kinase 4 inhibitor B(Cdkn2b)
貨號：

CSB-YP005092RA
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Cyclin-dependent kinase 4 inhibitor B(Cdkn2b)
貨號：

CSB-EP005092RA
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Cyclin-dependent kinase 4 inhibitor B(Cdkn2b)
貨號：

CSB-EP005092RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Cyclin-dependent kinase 4 inhibitor B(Cdkn2b)
貨號：

CSB-BP005092RA
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Cyclin-dependent kinase 4 inhibitor B(Cdkn2b)
貨號：

CSB-MP005092RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cdkn2b
Uniprot No.：

P55272
別名：

Cdkn2b; Ink4; Cyclin-dependent kinase 4 inhibitor B; p14-INK4b; p15-INK4b
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-130
氨基酸序列

MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV CDAWGRLPVD LAEEQGHRDI ARYLHAATGD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
基因功能參考文獻：
1. The P15 gene mutation was significantly correlated with osteosarcoma formation and metastasis. PMID: 26921270
2. Oviductus Ranae promotes the expression of P15 through a feedback mechanism to prevent excessive proliferation of hepatocytes in aged male rats. PMID: 20501390
3. Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats. PMID: 21147108
4. Northern analysis confirmed upregulation of PAI-1, P2X4, and P15INK4B in cultured alveolar epithelial type I cells (AT1); in whole lung, all three proteins were detected in alveolar epithelium in a location consistent with expression in AT1 cells PMID: 12600825
蛋白家族：

CDKN2 cyclin-dependent kinase inhibitor family
組織特異性：

Expression abundant in lung, less abundant in testis, barely detectable in liver, and not detectable in neonatal kidney, adult kidney, brain, heart, or spleen.
數據庫鏈接：

KEGG: rno:25164

STRING: 10116.ENSRNOP00000008898

UniGene: Rn.105626