Recombinant Rat Charged multivesicular body protein 4c (Chmp4c)

中文名稱：

Recombinant Rat Charged multivesicular body protein 4c(Chmp4c)
貨號：

CSB-YP710064RA
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Charged multivesicular body protein 4c(Chmp4c)
貨號：

CSB-EP710064RA
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Charged multivesicular body protein 4c(Chmp4c)
貨號：

CSB-EP710064RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Charged multivesicular body protein 4c(Chmp4c)
貨號：

CSB-BP710064RA
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Charged multivesicular body protein 4c(Chmp4c)
貨號：

CSB-MP710064RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Chmp4c
Uniprot No.：

Q569C1
別名：

Chmp4c; Charged multivesicular body protein 4c; Chromatin-modifying protein 4c; CHMP4c
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-232
氨基酸序列

MSKLGKFFKG SRSSRARAAP SAQEALARLR EIEEMMAKKQ EYLENRIQRE LALAKKHGSQ NKRAALQALK RKKRFEKQLT QIDGTLSTIE FQREALENSH TNTEVLRNMG FAAKAMKAVH ENMDLNKIDD LMQDITEQQD IAQEISEAFS QRVQFADGFD EDELLAELEE LEQEELNKKM TSMELPNVPS SSLPAQPSRK AGVPSSVHRS RAASSRRAEE DDDFKQLAAW AT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan.
亞細胞定位：

Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein. Midbody, Midbody ring.
蛋白家族：

SNF7 family
數據庫鏈接：

KEGG: rno:361916

STRING: 10116.ENSRNOP00000013720

UniGene: Rn.162567