Recombinant Rat Cdc42-interacting protein 4 (Trip10)

中文名稱：

大鼠Trip10重組蛋白
貨號：

CSB-YP024523RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Trip10重組蛋白
貨號：

CSB-EP024523RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Trip10重組蛋白
貨號：

CSB-EP024523RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Trip10重組蛋白
貨號：

CSB-BP024523RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Trip10重組蛋白
貨號：

CSB-MP024523RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Trip10
Uniprot No.：

P97531
別名：

Trip10; Cip4; StpCdc42-interacting protein 4; Salt tolerant protein; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-547
氨基酸序列

MDWGTELWDQ FEVLERHTQW GLDLLDKYVK FVKERVEVEQ SYAKQLRSLV KKYLPKRPAK DDPEIKFSQQ QSFVQLLQEV NDFAGQRELV AESLGIRVCL ELAKYSQEMK QERKMHFQEG RRAQQQLENG FKQLENSKRK FERDCREAEK AAHTAERLDQ DINATKADVE KAKQQAHLRN HMAEESKNEY AAQLQRFNRD QAHFYFSQMP QIFDKLQDMD ERRATRLGAG YGLLSEAELQ VVPIIGKCLE GMKVAAESVD AKNDSKVLIE LHKSGFARPG DLEFEDFSQV MNRVPSDSSL GTPDGRPELR AASSRSRAKR WPFGKKNKTV VTEDFSHLPP EQQRKRLQQQ LEERNRELQK EEDQREALKK MKDVYEKTPQ MGDPASLEPR IAETLGNIER LKLEVQKYEA WLAEAESRVL SNRGDSLSRH TRPPDPPTTA PPDSSSSSNN SGSQDNKESS EEPPSEEGQD TPIYTEFDED FEEPASPIGQ CVAIYHFEGS SEGTVSMSEG EDLSLMEEDK GDGWTRVRRK QGGEGYVPTS YLRVTLN
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Also acts as a link between CDC42 signaling and regulation of the actin cytoskeleton. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization in the vicinity of membrane tubules by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization and dynamin may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. May be required for the lysosomal retention of FASLG/FASL.
基因功能參考文獻：
1. ARHGAP12 negatively controls dendritic spine size via its RhoGAP activity and promotes, by interacting with CIP4, postsynaptic AMPA receptor endocytosis. PMID: 26854232
2. CIP4 is capable of inducing ECM deposition and exacerbating progressive fibrosis in chronic renal failure. PMID: 22745576
3. High-fat diet might have a relevance to insulin resistance by increasing the expression of PP2A and suppressing the expression of TC10 and CIP4 in the insulin-signaling cascade in the visceral adipose tissue. PMID: 18388891
4. a new role for Trip10, showing that the level of Trip10 expression is associated with the maintenance and differentiation of MSCs, was established. PMID: 20727853
亞細胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup.
蛋白家族：

FNBP1 family
組織特異性：

Expressed in adrenal gland, aorta, brain, heart, kidney, liver, skeletal muscle and spleen.
數據庫鏈接：

KEGG: rno:116717

UniGene: Rn.10814