Recombinant Rat CD40 ligand (Cd40lg), partial

中文名稱：

Recombinant Rat CD40 ligand(Cd40lg),partial
貨號：

CSB-YP004937RA
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat CD40 ligand(Cd40lg),partial
貨號：

CSB-EP004937RA
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat CD40 ligand(Cd40lg),partial
貨號：

CSB-EP004937RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat CD40 ligand(Cd40lg),partial
貨號：

CSB-BP004937RA
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat CD40 ligand(Cd40lg),partial
貨號：

CSB-MP004937RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cd40lg
Uniprot No.：

Q9Z2V2
別名：

Cd40lg; Cd40l; Tnfsf5CD40 ligand; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form; sCD40L)]
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.; Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
基因功能參考文獻：
1. Transient middle cerebral artery occlusion (MCAO) rats yielded an acceleration of thrombus formation that was accompanied by increased CD40 levels in serum. The brain infarction was significantly decreased in CD40 antagonist treatment group compared to MCAO model group. The mTOR/S6K signaling was activated in MACO model than that of CD40 antagonist treatment group. PMID: 29843579
2. Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in focal segmental glomerulosclerosis. PMID: 29155846
3. Suggest that CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury. PMID: 25993320
4. These data suggest that placental ischemia-induced T-cell communication via the CD40L is one important mechanism leading to much of the pathophysiology of preeclampsia. PMID: 26310940
5. PSB33 functions in the maintenance of photosystem II-light-harvesting complex II.[PSB33] PMID: 25511433
6. Data suggest that astrocytes activated by CD40-CD40L in co-culture induce inflammatory cytokine production, and secreted cytokines re-activate astrocytes via Jak/STAT1701 pathways, and release more cytokines that contribute to the development of EAE. PMID: 21410936
7. Monoclonal antibodies are immunosuppressive in pig to rat islet xenograft. PMID: 15665763
8. B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated experimental autoimmune neuritis of Lewis rats PMID: 17188497
9. HO-1 mitigated CD40L transcription in the xenograft and recipient spleen. PMID: 17976119
10. Generated and characterized a novel anti-rat CD40L antibody with inhibitory activities. PMID: 18384807
11. Adenovirus-mediated Cd40lg gene therapy induced both humoral and cellular immunity against rat model of hepatocellular carcinoma. PMID: 19016771
12. Primary tumor cells obtained from MNU-induced mammary carcinomas show immune heterogeneity which can be modulated by low-efficiency transfection of CD40L gene. PMID: 19164932
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亞細胞定位：

Cell membrane; Single-pass type II membrane protein. Cell surface.; [CD40 ligand, soluble form]: Secreted.
蛋白家族：

Tumor necrosis factor family
數據庫鏈接：

KEGG: rno:84349

STRING: 10116.ENSRNOP00000001162

UniGene: Rn.44218