Recombinant Rabbit Methylosome subunit pICln (CLNS1A)

中文名稱：

Recombinant Rabbit Methylosome subunit pICln(CLNS1A)
貨號：

CSB-YP637913RB
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rabbit Methylosome subunit pICln(CLNS1A)
貨號：

CSB-EP637913RB-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rabbit Methylosome subunit pICln(CLNS1A)
貨號：

CSB-BP637913RB
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rabbit Methylosome subunit pICln(CLNS1A)
貨號：

CSB-MP637913RB
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

CLNS1A
Uniprot No.：

Q28678
別名：

CLNS1A; ICLN; Methylosome subunit pICln; Chloride channel; nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln)
種屬：

Oryctolagus cuniculus (Rabbit)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-236
氨基酸序列

SFLKSFPPP GPTEGLRHQQ PDTEAVLNGK GLGTGTLYIA ESRLSWLDGS GLGFSLEYPT ISLHAVSRDP NAYPQEHLYV MVNAKFGEES KELVADEEED SDDDVEPISE FRFVPGDKSA LEAMFTAMCE CQALHPDPED EDSDDYDGEE YDVEAHEQGQ GDIPTFYTYE EGLSHLTAEG QATLERLEGM LSQSVSSQYN MAGVRTEDSI RDYEDGMEVD TTPTVAGQFE DADVDH
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
亞細(xì)胞定位：

Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton.
蛋白家族：

PICln (TC 1.A.47) family
組織特異性：

Widely distributed but expressed more abundantly in nonpigmented ciliary epithelial cells than in pigmented ones.
數(shù)據(jù)庫鏈接：

STRING: 9986.ENSOCUP00000017064

UniGene: Ocu.6802