Recombinant Rabbit Helicase-like transcription factor (HLTF), partial

中文名稱：

小圓錐花果HLTF重組蛋白
貨號：

CSB-YP010520RB
規格：
來源：

Yeast
其他：

中文名稱：

小圓錐花果HLTF重組蛋白
貨號：

CSB-EP010520RB
規格：
來源：

E.coli
其他：

中文名稱：

小圓錐花果HLTF重組蛋白
貨號：

CSB-EP010520RB-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小圓錐花果HLTF重組蛋白
貨號：

CSB-BP010520RB
規格：
來源：

Baculovirus
其他：

中文名稱：

小圓錐花果HLTF重組蛋白
貨號：

CSB-MP010520RB
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HLTF
Uniprot No.：

Q95216
別名：

HLTF; RUSH1; SMARCA3; Helicase-like transcription factor; EC 2.3.2.27; EC 3.6.4.-; RING-type E3 ubiquitin transferase HLTF; RUSH-1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3
種屬：

Oryctolagus cuniculus (Rabbit)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. Transcriptional regulator that mediates the ability of prolactin to augment progesterone-dependent transcription of the SCGB1A1/uteroglobin gene through a bipartite progesterone receptor half-site/overlapping Y-box combination (-38/-26) where progesterone activation is attenuated by nuclear factor Y binding. Regulation also involves two GC-rich sequences in the proximal promoter (positions -162/+90) and a RUSH/SMARCA3 site (positions -616/-611) in the 5'-untranslated region.
基因功能參考文獻：
1. Prolactin dependent Jak2 phosphorylation of RUSH. PMID: 20562009
2. Splice arrays and RT-PCR showed that although most splice variants in RUSH and ATP11B are conserved in human and rabbit, the RFBP isoform is specific to rabbit. PMID: 18584949
亞細胞定位：

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Cytoplasmic and nuclear localization in the presence of prolactin. Nuclear localization is stimulated by progesterone.
蛋白家族：

SNF2/RAD54 helicase family, RAD16 subfamily
組織特異性：

Isoform 1 is expressed preferentially in bladder, cervix, diaphragm, duodenum, epididymis, heart, kidney, liver, lung, ovary (granulosa cells), prostate, spleen, testis (predominantly in the Sertoli cells of the seminiferous tubules) and vagina. Isoform 2
數據庫鏈接：

KEGG: ocu:100009232

STRING: 9986.ENSOCUP00000003055

UniGene: Ocu.2614