Recombinant Rabbit C-C motif chemokine 2 (CCL2)

中文名稱：

Recombinant Rabbit C-C motif chemokine 2(CCL2)
貨號(hào)：

CSB-YP004783RB
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

Recombinant Rabbit C-C motif chemokine 2(CCL2)
貨號(hào)：

CSB-EP004783RB
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

Recombinant Rabbit C-C motif chemokine 2(CCL2)
貨號(hào)：

CSB-EP004783RB-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rabbit C-C motif chemokine 2(CCL2)
貨號(hào)：

CSB-BP004783RB
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

Recombinant Rabbit C-C motif chemokine 2(CCL2)
貨號(hào)：

CSB-MP004783RB
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

CCL2
Uniprot No.：

P28292
別名：

CCL2; SCYA2C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; Small-inducible cytokine A2
種屬：

Oryctolagus cuniculus (Rabbit)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

24-125
氨基酸序列

QPDAVNS PVTCCYTFTN KTISVKRLMS YRRINSTKCP KEAVIFMTKL AKGICADPKQ KWVQDAIANL DKKMQTPKTL TSYSTTQEHT TNLSSTRTPS TTTSL
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B.
基因功能參考文獻(xiàn)：
1. Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site. PMID: 26728372
2. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group. PMID: 25270202
3. measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV. PMID: 19929801
4. Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression. PMID: 19467827
亞細(xì)胞定位：

Secreted.
蛋白家族：

Intercrine beta (chemokine CC) family
數(shù)據(jù)庫(kù)鏈接：

KEGG: ocu:100009130

STRING: 9986.ENSOCUP00000015636

UniGene: Ocu.1921