Recombinant Mouse Vitamin D-binding protein (Gc)

^{In
Stock}

中文名稱：

小鼠Gc重組蛋白
品名簡稱：

Recombinant Mouse Vitamin D-binding protein
貨號：

CSB-YP009306MO
說明書：

MSDS Datasheet
規格：

￥2208
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The purity of Gc was greater than 95% as determined by SEC-HPLC
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
Greater than 95% as determined by SEC-HPLC.
基因名：

Gc
Uniprot No.：

P21614
別名：

Gc; Vitamin D-binding protein; DBP; VDB; Gc-globulin; Group-specific component
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

Yeast
分子量：

53.9kDa
表達區域：

17-476aa
氨基酸序列

LERGRDYEKDKVCNELAMLGKEDFRSLSLILYSRKFSSSTFEQVNQLVKEVVSLTEECCAEGADPTCYDTRTSELSVKSCESDAPFPVHPGTPECCTKEGLERKLCMAALSHQPQEFPTYVEPTNDEICEAFRRDPKGFADQFLYEYSSNYGQAPLPLLVAYTKNYLSMVGSCCTSANPTVCFVKERLQMKHLSLLTTMSNRVCSQYAAYGKEKSRLSHLIKLAQKVPTANLENVLPLAEDFTEILSRCCESTSEDCMASELPEHTIKICQNLSKKNSKFEECCQENTPMNIFMCTYFMPAAEPLQLPAIKLPTGKDLCGQSTTQAMDQYTFELSRRTQVPEVFLSKVLEPTLKTLRECCDTQDSVACFSTQSPLLKRQLTSFIEKGQEMCADYSENTFTEYKKKLAERLRTKTPNTSPAELKDMVEKHSDFASKCCSINSPPLYCSSQIDAEMIDTLQS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產品描述：

Recombinant Mouse Vitamin D-binding protein (Gc) carrying an N-terminal 6xHis-tag is a full-length of mature protein expressed in the yeast. The expression region of the protein is the Leu17 to Ser476 aa of Gc protein of mouse-origin. It got purified by SDS-PAGE and reaches up to 85% in purity. This recombinant Gc protein is in stock and customers can purchase it directly without waiting period of product preparation.

Vitamin D binding protein (DBP), also known as Group-specific Component (Gc), is the major transport protein for all vitamin D metabolites in the blood. And it is essential for the utilization of vcutaneous produced vitamin D. DBP's tight binding of actin creates a DPB-Actin complex, which avoids actin polymerization in serum after tissue damage. The polymorphisms of DBP have been related to susceptibility or resistance to numerous chronic diseases, such as osteoporosis, type 1, and type 2 diabetes.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
基因功能參考文獻：
1. results show DBP is a significant chemotactic cofactor in vivo and not specific for C5a, suggesting that this ubiquitous plasma protein may have a more significant role in neutrophil recruitment than previously recognized PMID: 23752613
2. Effects of estradiol on the endocytic transport of vitamin D carrier protein in hepatocytes. PMID: 23416408
3. Data suggest that whereas DBP is important to total circulating 1,25(OH)(2)D(3) and sequesters extracellular levels of this hormone both in vivo and in vitro, the binding protein does not influence the hormone's biologically active pool. PMID: 18372326
亞細胞定位：

Secreted.
蛋白家族：

ALB/AFP/VDB family
數據庫鏈接：

KEGG: mmu:14473

STRING: 10090.ENSMUSP00000046636

UniGene: Mm.196595