Recombinant Mouse Tripartite motif-containing protein 14 (Trim14)

中文名稱：

小鼠Trim14重組蛋白
貨號：

CSB-YP803945MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Trim14重組蛋白
貨號：

CSB-EP803945MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Trim14重組蛋白
貨號：

CSB-EP803945MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Trim14重組蛋白
貨號：

CSB-BP803945MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Trim14重組蛋白
貨號：

CSB-MP803945MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Trim14
Uniprot No.：

Q8BVW3
別名：

Trim14; Kiaa0129; Pub; Tripartite motif-containing protein 14; PU.1-binding protein
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-440
氨基酸序列

MASETTEARA PFQPDGAYGW RCPEHSERPA ELFCRRCGRC VCALCPVLGA HRGHPVGLAE EEAVRVQKLI QDCLECLATK KRQHADNIAH LEDAGERLKV YADSSKAWLT QKFTELRLLL DEEEVLAKKF IDKSTQLTLQ VYREQAETCG KQIEVMDDFS TRVWGIGQEP NPVQLLQAYI ATKTEMGQQM SPSELSHPVP LSFEPVKNFF KEFVEAIGNT LQTPMDTRLK ENINCQLSNS SSTKPGALLK TSPSPERALF LKYARTPTLD PDTMHARLRL SPDGLTVRCS LLGRLGPRPA PRFDALRQVL GRDGFAAGRH YWEVDVQEAG VGWWVGAAYP SLRRRGASAA ARLGCNRESW CVKRYDLEYW AFHDGQRSRL RPRRDPHRLG VFLDYEAGIL AFYDVAGGMS HLHTFHAAFQ EPLYPALRLW EGPISIPRLP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.; Plays an essential role in the innate immune defense against viruses and bacteria. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.
基因功能參考文獻：
1. study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response PMID: 28476934
2. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses. PMID: 27666593
3. These results demonstrate the presence of the similar mechanism of trim14 gene action in different types of mammalian cells. PMID: 24092016
4. Pub gene participates in early stages of differentiation of embryonic stem cells leading to the formation of embryoid bodies. PMID: 16254642
亞細胞定位：

Mitochondrion outer membrane. Cytoplasmic vesicle, phagosome.
蛋白家族：

TRIM/RBCC family
組織特異性：

Expressed with high level in spleen, thymus, liver and testis. Expressed with low level in the brain, kidney, and skeletal muscle. Expressed in various differentiation stages of B-lymphocytes.
數據庫鏈接：

KEGG: mmu:74735

STRING: 10090.ENSMUSP00000038719

UniGene: Mm.240252