Recombinant Mouse Translocation protein SEC63 homolog (Sec63), partial

中文名稱：

小鼠Sec63重組蛋白
貨號：

CSB-YP837736MO1
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Sec63重組蛋白
貨號：

CSB-EP837736MO1
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Sec63重組蛋白
貨號：

CSB-EP837736MO1-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Sec63重組蛋白
貨號：

CSB-BP837736MO1
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Sec63重組蛋白
貨號：

CSB-MP837736MO1
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Sec63
Uniprot No.：

Q8VHE0
別名：

Sec63; Sec63l; Translocation protein SEC63 homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia.
基因功能參考文獻：
1. SEC63 function regulates IRE1alpha/XBP1 activation. SEC63 and XBP1 are required for GPS cleavage and maturation of PC1, protecting against polycystic disease. PMID: 25844898
2. The pro-carcinogenic growth behavior of hepatocytes with low SEC63 expression in the murine model indicates a potential role for SEC63 in hepatocarcinogenesis in general. PMID: 23537056
3. Knockout of the murine Sec63 gene inhibits transport of precursor proteins into the endoplasmic reticulum. PMID: 22375059
4. SEC63 gene expression is up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy. PMID: 19208265
亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
組織特異性：

Expressed in kidney (at protein level).
數據庫鏈接：

KEGG: mmu:140740

STRING: 10090.ENSMUSP00000019937

UniGene: Mm.214344