Recombinant Mouse Thioredoxin, mitochondrial (Txn2)

中文名稱：

小鼠Txn2重組蛋白
貨號：

CSB-YP025366MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Txn2重組蛋白
貨號：

CSB-EP025366MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Txn2重組蛋白
貨號：

CSB-EP025366MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Txn2重組蛋白
貨號：

CSB-BP025366MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Txn2重組蛋白
貨號：

CSB-MP025366MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Txn2
Uniprot No.：

P97493
別名：

Txn2; Thioredoxin; mitochondrial; MTRX; Mt-Trx; Thioredoxin-2
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

60-166
氨基酸序列

T TFNVQDGPDF QDRVVNSETP VVVDFHAQWC GPCKILGPRL EKMVAKQHGK VVMAKVDIDD HTDLAIEYEV SAVPTVLAIK NGDVVDKFVG IKDEDQLEAF LKKLIG
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
基因功能參考文獻：
1. The ventral signal observed from early stages colocalized with motor neuron markers Isl1/2 and FoxP1 and the strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord. PMID: 25975898
2. TRX-2 overexpression does not mitigate adverse effects of a high-calorie diet on synaptic plasticity PMID: 26476179
3. An essential role was identified for thioredoxin-2 in preserving cardiac function by suppressing mitochondrial reactive oxygen species. PMID: 25628390
4. This study shows that both fructose and glucose-sweetened liquid consumption results in fatty liver and upregulated thioredoxin-2 expression. PMID: 22254090
5. Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3. PMID: 20929858
6. Data show that Nrf2 activity was increased in WT MEFs at the 0 or -46 mV conditions, but was inhibited in Trx2 Tg MEFs under the same conditions. PMID: 19778293
7. Homozygous mutant embryos do not survive to birth and die after implantation at Theiler stage 15/16. PMID: 12529397
8. the rapid E2-mediated activation of the Txn pathway is an important step in the response of the mammalian uterus to estrogen. PMID: 15345672
9. Trx2 is an endogenous regulator of the mitochondrial permeability transition. PMID: 18550601
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亞細胞定位：

Mitochondrion.
蛋白家族：

Thioredoxin family
數據庫鏈接：

KEGG: mmu:56551

STRING: 10090.ENSMUSP00000005487

UniGene: Mm.291917