Recombinant Mouse Tachykinin-3 (Tac3)

中文名稱：

小鼠Tac3重組蛋白
貨號：

CSB-YP023063MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Tac3重組蛋白
貨號：

CSB-EP023063MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Tac3重組蛋白
貨號：

CSB-EP023063MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Tac3重組蛋白
貨號：

CSB-BP023063MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Tac3重組蛋白
貨號：

CSB-MP023063MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tac3
Uniprot No.：

P55099
別名：

Tac3; Nknb; Tac2; Tachykinin-3; Neurokinin B-like protein Zneurok1; Preprotachykinin-B; PPT-B) [Cleaved into: Neurokinin-B; NKB; Neuromedin-K)]
種屬：

Mus musculus (Mouse)
蛋白長度：

Cytoplasmic domain
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function.
基因功能參考文獻：
1. steroidal environment and energy state negatively regulate kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) gene expression. PMID: 27507595
2. This study showed a new evidence that furthers our understanding for the mechanisms underlying Tac2-dependent cellular pathways in fear learning. PMID: 27238620
3. Data show that estrogen receptor alpha (ERalpha) in tachykinin 2 protein (Tac2) neurons typically restrains pubertal onset and hypothalamic reproductive drive. PMID: 26862996
4. Tac2-/- females had delays in sexual maturation, with time to vaginal opening and first estrus occurring later than controls. However, cycling recovered in adulthood and Tac2-/- females were fertile, although they produced fewer pups per litter. PMID: 25574869
5. Increased Tac2 expression, through a stress-induced PTSD-like model, or following lentiviral CeA overexpression, are sufficient to enhance fear consolidation. PMID: 24976214
6. Data indicate that in the arcuate nucleus, nearly 80% of enhanced green fluorescent protein (EGFP) neurons expressed pro-neurokinin B (NKB)-immunoreactivity. PMID: 24735328
7. Data suggest that activation of neurokinin 3 and kappa-opioid receptors (NK3R and KOR) excites and inhibits kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons). PMID: 23744642
8. NKB could directly regulate secretion from NK3R-expressing GnRH neurons. PMID: 23393128
9. Tac2 homozygous null mice responded normally to a series of algogenic (pain-inducing) and pruritic (itch-inducing) stimuli. PMID: 22272772
10. Preprotachykinin (PPT)-B genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function. PMID: 12773411
11. neurokinin B PMID: 16160861
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亞細胞定位：

Secreted.
蛋白家族：

Tachykinin family
數據庫鏈接：

KEGG: mmu:21334

STRING: 10090.ENSMUSP00000026466

UniGene: Mm.2374