Recombinant Mouse Serine/threonine-protein kinase PAK 7 (Pak7)

中文名稱：

小鼠Pak5重組蛋白
貨號：

CSB-YP805374MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Pak5重組蛋白
貨號：

CSB-EP805374MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Pak5重組蛋白
貨號：

CSB-EP805374MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Pak5重組蛋白
貨號：

CSB-BP805374MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Pak5重組蛋白
貨號：

CSB-MP805374MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pak5
Uniprot No.：

Q8C015
別名：

Pak5; Pak7; Serine/threonine-protein kinase PAK 5; EC 2.7.11.1; p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-719
氨基酸序列

MFGKKKKKIE ISGPSNFEHR VHTGFDPQEQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT PIQLAPMKTI VRGNKSCKET SINGLLEDFD NISVTRSNSL RKESPPTPDQ GAASRIQGHS EENGFITFSQ YSSESDTTAD YTTEKYRDRS LYGDDLDLYY KSSHAAKQNG HAMKMKHGDA YYPEMKSLKT DLAGFPVDYH THLDSLRKSS EYGDLRWDYQ RASSSSPLDY SFQLTPSRTA GTSRCSKESL AYSESDWGPS LDDYDRRPKS SYLHQTSPQP AMRQRSKSGS GLQEPMMPFG ASAFKTHPQG HSYNSYTYPR LSEPTMCIPK VDYDRAQMVF SPPLSGSDTY PRGPTKLPQS QSKAGYSSGS HQYPSGYHKA SLYHHPSLQT SSQYISTASY LSSLSISSST YPPPSWGSSS DQQPSRVSHE QFRAALQLVV SPGDPREYLD NFIKIGEGST GIVCIATEKH TGKQVAVKKM DLRKQQRREL LFNEVVIMRD YHHDNVVDMY NSYLVGDELW VVMEFLEGGA LTDIVTHTRM NEEQIATVCL SVLKALSYLH NQGVIHRDIK SDSILLTSDG RIKLSDFGFC AQVSKEVPKR KSLVGTPYWM APEVISRLPY GTEVDIWSLG IMVIEMIDGE PPYFNEPPLQ AMRRIRDSLP PRVKDLHKVS SMLRGFLDLM LVREPSQRAT AQELLGHPFL KLAGPPSCIV PLMRQYRHH
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
基因功能參考文獻：
1. PAK-7 p21-activated kinase 5 knockout mice are more sensitive to the stimulant effects of amphetamine PMID: 23710594
2. PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific transient receptor potential-channels. PMID: 22732262
3. PAK5 may provide a molecular rationale for late-stage complications in diabetes. PMID: 15615695
亞細胞定位：

Mitochondrion. Cytoplasm. Nucleus.
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
組織特異性：

Highly expressed in brain and eye. Also expressed in adrenal gland, pancreas, prostate and testes. Within the brain, expression is restricted to neurons. Present in brain but not in kidney, lung and spleen (at protein level).
數(shù)據(jù)庫鏈接：

KEGG: mmu:241656

STRING: 10090.ENSMUSP00000047285

UniGene: Mm.131572