Recombinant Mouse Renalase (Rnls)

中文名稱：

小鼠Rnls重組蛋白
貨號：

CSB-YP417267MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Rnls重組蛋白
貨號：

CSB-EP417267MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Rnls重組蛋白
貨號：

CSB-BP417267MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Rnls重組蛋白
貨號：

CSB-MP417267MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rnls
Uniprot No.：

A7RDN6
別名：

Rnls; Renalase; EC 1.6.3.5; Monoamine oxidase-C; MAO-C; mMAO-C
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

18-342
氨基酸序列

ALL RKEITAPLYL GLWDKGGDIG GRMITASSPH NPRCTADLGA QYITCSPHYV KEHQNFYEEL LAHGILKPLT SPIEGMKGKE GDCNFVAPQG FSSVIKYYLK KSGAEVSLKH CVTQIHLKDN KWEVSTDTGS AEQFDLVILT MPAPQILELQ GDIVNLISER QREQLKSVSY SSRYALGLFY EVGMKIGVPW SCRYLSSHPC ICFISIDNKK RNIESSECGP SVVIQTTVPF GVQHLEASEA DVQKLMIQQL ETILPGLPQP VATICHKWTY SQVTSSVSDR PGQMTLHLKP FLVCGGDGFT HSNFNGCISS ALSVMKVLKR YI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
基因功能參考文獻：
1. Data (including data from studies in knockout mice) suggest that renalase functions as a protective plasma protein that reduces pancreatic acinar cell injury and prevents pancreatitis via interactions with plasma membrane calcium ATPase Pmca4b. PMID: 29042438
2. High RNLS expression is associated with melanoma. PMID: 27197188
3. revealed renalase as a novel target gene of HIF-1alpha in protection against myocardial ischaemia/reperfusion injury PMID: 25497549
4. Renalase promotes cell survival and protects against renal injury in mice through the activation of intracellular signaling cascades, independent of its ability to metabolize catecholamines. PMID: 24511138
5. Renalase is wildly expressed in kidney, including glomeruli, tubule, mesangial cells, podocytes and tubule epithelial cells, and may be secreted by tubule epithelial cells primarily PMID: 23056310
6. the identification of a renalase homologue from mouse, termed mMAO-C (mouse monoamine oxidase-C) after the monoamine oxidase-A and -B (MAO-A and -B PMID: 17846919
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亞細胞定位：

Secreted.
蛋白家族：

Renalase family
組織特異性：

Expressed predominantly in kidney and testis with lower levels in liver, heart and embryo and weak expression in brain and skeletal muscle.
數據庫鏈接：

KEGG: mmu:67795

STRING: 10090.ENSMUSP00000093825

UniGene: Mm.204591