Recombinant Mouse Rab GTPase-binding effector protein 1 (Rabep1), partial

中文名稱：

小鼠Rabep1重組蛋白
貨號：

CSB-YP019228MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Rabep1重組蛋白
貨號：

CSB-EP019228MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Rabep1重組蛋白
貨號：

CSB-EP019228MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Rabep1重組蛋白
貨號：

CSB-BP019228MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Rabep1重組蛋白
貨號：

CSB-MP019228MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rabep1
Uniprot No.：

O35551
別名：

Rabep1; Rab5ep; Rabpt5; Rabpt5a; Rab GTPase-binding effector protein 1; Rabaptin-5; Rabaptin-5alpha
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium.
基因功能參考文獻：
1. novel protein complex composed of Rabep1, GGA1 and Arl3 is responsible for the sorting and targeting of the polycystin 1 andpolycystin 2 to the cilium. PMID: 25405894
2. The intracellular localization of Rabaptin-5gamma indicates that it is not involved in Rab5-driven events--rather, it functions in other membrane transport steps; role of alternative splicing in determination of functional activities of Rab effector molecules PMID: 25385014
3. our results assign Rab5 a key role in mediating mast cell secretory granule fusion during biogenesis PMID: 24696234
4. Rabex-5 regulates neurite morphogenesis of hippocampal neurons by activating at least two downstream targets, Rab5, which is localized in both axons and dendrites, and Rab17, which is localized in dendrites alone PMID: 23430262
5. The disruption of Rabaptin-5 Ser407 phosphorylation reduces persistent cell migration in 2D and alphavbeta3-dependent invasion. PMID: 22975325
6. Data reveal the affinity of Rabex-5/Rabaptin-5/Rab5-GTP interaction in the cell, which is quantitatively related to the Rabex-5 concentration for the onset of the indirect positive feedback pathway. PMID: 20169068
7. Western blot analysis of the mouse brain showed reduced levels of calpastatin and rabaptin-5 and higher amount of neuronatin in PKU compared to the wild type. PMID: 15863237
8. Rabaptin-5 importantly contributes to mast cell IgE-dependent immunologic function by enhancing mast cell receptor surface stability. PMID: 18698003
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亞細胞定位：

Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle.
蛋白家族：

Rabaptin family
數據庫鏈接：

KEGG: mmu:54189

STRING: 10090.ENSMUSP00000075619

UniGene: Mm.7087