Recombinant Mouse Myotubularin-related protein 14 (Mtmr14)

中文名稱：

小鼠Mtmr14重組蛋白
貨號：

CSB-YP823758MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Mtmr14重組蛋白
貨號：

CSB-EP823758MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Mtmr14重組蛋白
貨號：

CSB-EP823758MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Mtmr14重組蛋白
貨號：

CSB-BP823758MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Mtmr14重組蛋白
貨號：

CSB-MP823758MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mtmr14
Uniprot No.：

Q8VEL2
別名：

Mtmr14; Myotubularin-related protein 14; EC 3.1.3.-; mJumpy
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-648
氨基酸序列

MAGARAAAAA SAGSTASSGS PPPQEPGLWE LLEEFSRTQY RAKDSGGKSG SKVERIEKRC LELFGRDYCF SVIPNVNGDI CGHYPRHIVF LEYESSEKEK DTFQSTVQVN KLQDLIHRSK MARCRGRFVC PVILFKGKHI CRSATLAGWG ELYGRSGYNY LFSGGADDTW ASTEDVTEED FVLRSGDTHL FDKVRGYDIK LLQYLSVKYI CDLMVENKKV KFGMNVTSSE KVDKAQRYAN FTLLSIPYPG CEFFKEYKDR DYMAEGLIFN WKQDYVDAPL NIPNFLTQSL NIDWSQYQSW DLVQQTQNYL KLLLFIMNRD DDSGLLVHCI SGWDRTPLFI SLLRLSLWAD GLIHTSLKPA EILYLTVAYD WFLFGHMLVD RLSKGEEIFF FCFNFLKHIT SEEFCLKTQR RKSLPTRDAG FTVEDICMLR HKDRGSTTSL GSDFSLVLEH SPGAVGSFSY ETVELAPAGA PTQAAWRKSH SSSPQSMLWS RPQPSEERLP SHHGLTEAKS SSSSSSNHSD NFFRMGSSPL EVPKPRSVDH PLPGSSLSTD FGSWQLVSGC GSIQDRPVLH TDSSLPFSFQ DELPNSCLLT ALSDRETRLQ EVRSAFLAAY SSTVGLRAAT PSPSGAIGGL LEQFARGVGL RGTSTSTL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
基因功能參考文獻：
1. Data (including data from studies in knockout mice) suggest that Mtmr14 plays role in lipid metabolism and inflammation in liver, skeletal muscle, and adipose tissue in obesity induced by high-fat diet (HFD); here, Mtmr14 deficiency in knockout mice accelerates HFD-induced inflammation and metabolic dysfunction (obesity, hyperglycemia, and hyperlipidemia). PMID: 27807764
2. propose that defect of MTMR14 promotes autophagy and cell proliferation in MEFs PMID: 24623267
3. In young Mtmr14 KO mice (12 weeks). The T-tubule dysmorphology (swollen and elongated) could explain, in part, the defects in Ca2thorn excitationcontraction machinery observed in previous studies. PMID: 21930146
4. a knockout mice were more susceptible to exercise-induced muscle damage, a trademark of muscle functional changes in older subjects PMID: 20817957
5. MTMR14 may play an important role in muscle calcium homeostasis. PMID: 20834069
6. Data report that mice deficient in the newly identified phosphatidylinositol phosphate phosphatase MIP/MTMR14 (muscle-specific inositol phosphatase) show muscle weakness and fatigue. PMID: 19465920
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亞細胞定位：

Cytoplasm.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
數據庫鏈接：

KEGG: mmu:97287

STRING: 10090.ENSMUSP00000108771

UniGene: Mm.197816