Recombinant Mouse Lysosomal-trafficking regulator (Lyst), partial

中文名稱：

小鼠Lyst重組蛋白
貨號：

CSB-YP013281MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Lyst重組蛋白
貨號：

CSB-EP013281MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Lyst重組蛋白
貨號：

CSB-EP013281MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Lyst重組蛋白
貨號：

CSB-BP013281MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Lyst重組蛋白
貨號：

CSB-MP013281MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lyst
Uniprot No.：

P97412
別名：

Lyst; Bg; Chs1Lysosomal-trafficking regulator; Beige protein; CHS1 homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes. Might regulate trafficking of effectors involved in exocytosis. In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules. In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes. In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways.
基因功能參考文獻(xiàn)：
1. Lyst as a specific regulator of TLR3- and TLR4-mediated TRIF signaling pathways reveals how the regulation of the intracellular membrane trafficking network is functionally linked to specific TLR signaling pathways. PMID: 27881733
2. results identify an association between oxidative damage to lipid membranes and the severity of Lyst-mutant phenotypes, revealing a new mechanism that contributes to pathophysiology involving LYST PMID: 20617205
3. the Lyst(Ing3618 )allele could represent a new model for adult Chediak-Higashi syndrome with neurological impairment PMID: 16791600
4. Apolipoprotein E (ApoE)-deficient beige mice have markedly reduced development of atherosclerotic lesions when fed a chow diet; expression of the beige mutation in all cell types involved in lesion development contributes to atheroprotection. PMID: 17982137
5. The upregulation of LYST/Beige in infected cells functions as a host innate response to limit parasite growth. PMID: 18927622
6. These results demonstrated that mutation of the Lyst gene can produce ocular features of human XFS (exfoliation syndrome) and suggested that LYST or LYST-interacting genes may contribute to XFS. PMID: 19029039
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相關(guān)疾病：

Defects in Lyst are the cause of beige, an autosomal recessive disorder characterized by hypopigmentation, bleeding, immune cell dysfunction, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types.
亞細(xì)胞定位：

Cytoplasm.
組織特異性：

Expressed in the heart, lung, liver, spleen, brain and in different immune cell types (purified B and T lymphocytes, bone marrow-derived macrophages and dendritic cells).
數(shù)據(jù)庫鏈接：

KEGG: mmu:17101

STRING: 10090.ENSMUSP00000106188

UniGene: Mm.342337