Recombinant Mouse Liver carboxylesterase 1 (Ces1)

中文名稱：

Recombinant Mouse Liver carboxylesterase 1(Ces1)
貨號：

CSB-YP848671MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Liver carboxylesterase 1(Ces1)
貨號：

CSB-EP848671MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Liver carboxylesterase 1(Ces1)
貨號：

CSB-BP848671MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Liver carboxylesterase 1(Ces1)
貨號：

CSB-MP848671MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ces1
Uniprot No.：

Q8VCC2
別名：

Ces1; Ces1gLiver carboxylesterase 1; EC 3.1.1.1; Acyl-coenzyme A:cholesterol acyltransferase; Carboxylesterase 1G; ES-x
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

19-565
氨基酸序列

HP SLPPVVHTVH GKVLGKYVTL EGFSQPVAVF LGVPFAKPPL GSLRFAPPEP AEPWSFVKHT TSYPPLCYQN PEAALRLAEL FTNQRKIIPH KFSEDCLYLN IYTPADLTQN SRLPVMVWIH GGGLVIDGAS TYDGVPLAVH ENVVVVVIQY RLGIWGFFST EDEHSRGNWG HLDQVAALHW VQDNIANFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAIAQSSVI FNPCLFGRAA RPLAKKIAAL AGCKTTTSAA MVHCLRQKTE DELLEVSLKM KFGTVDFLGD PRESYPFLPT VIDGVLLPKA PEEILAEKSF NTVPYMVGIN KHEFGWIIPM FLDFPLSERK LDQKTAASIL WQAYPILNIS EKLIPAAIEK YLGGTEDPAT MTDLFLDLIG DIMFGVPSVI VSRSHRDAGA PTYMYEYQYR PSFVSDDRPQ ELLGDHADEL FSVWGAPFLK EGASEEEINL SKMVMKFWAN FARNGNPNGE GLPHWPEYDQ KEGYLQIGVP AQAAHRLKDK EVDFWTELRA KETAERSSHR EHVEL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile.
基因功能參考文獻：
1. Loss of CES1 is associated with the susceptibility to high cholesterol diet-induced liver injury. PMID: 27881673
2. Hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin sensitivity. PMID: 26976727
3. Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses. PMID: 24194565
4. Hepatic CES1 plays a critical role in regulating both lipid and carbohydrate metabolism and FXR-controlled lipid homeostasis PMID: 24038130
5. Ces1/Es-x participates in the regulation of chylomicron assembly and secretion. PMID: 23145182
6. These studies support a role for Ces1/Es-x in the partitioning of regulatory fatty acids and concomitant control of hepatic lipid biosynthesis, secretion, and deposition. PMID: 22806626
7. Es-x limits hepatic triacylglycerol accumulation by promoting beta-oxidation. PMID: 19651238
顯示更多

收起更多
亞細胞定位：

Endoplasmic reticulum lumen. Cytoplasm. Lipid droplet.
蛋白家族：

Type-B carboxylesterase/lipase family
組織特異性：

Detected in kidney, liver and lung.
數(shù)據(jù)庫鏈接：

KEGG: mmu:12623

UniGene: Mm.22720