Recombinant Mouse Lipopolysaccharide-binding protein (Lbp)

中文名稱：

小鼠Lbp重組蛋白
貨號(hào)：

CSB-YP717228MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Lbp重組蛋白
貨號(hào)：

CSB-EP717228MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Lbp重組蛋白
貨號(hào)：

CSB-EP717228MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Lbp重組蛋白
貨號(hào)：

CSB-BP717228MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Lbp重組蛋白
貨號(hào)：

CSB-MP717228MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lbp
Uniprot No.：

Q61805
別名：

LbpLipopolysaccharide-binding protein; LBP
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

25-481
氨基酸序列

GVNPGV VARITDKGLA YAAKEGLVAL QRELYKITLP DFSGDFKIKA VGRGQYEFHS LEIQNCELRG SSLKLLPGQG LSLAISDSSI GVRGKWKVRK SFLKLHGSFD LDVKGVTISV DLLLGMDPSG RPTVSASGCS SRICDLDVHI SGNVGWLLNL FHNQIESKLQ KVLENKVCEM IQKSVTSDLQ PYLQTLPVTA EIDNVLGIDY SLVAAPQAKA QVLDVMFKGE IFNRNHRSPV ATPTPTMSLP EDSKQMVYFA ISDYAFNIAS RVYHQAGYLN FSITDDMLPH DSGIRLNTKA FRPFTPQIYK KYPDMKLELL GTVVSAPILN VSPGNLSLAP QMEIEGFVIL PTSAREPVFR LGVVTNVFAS LTFNNSKVTG MLHPDKAQVR LIESKVGMFN VNLFQAFLNY YLLNSLYPDV NAELAQGFPL PLPRHIQLHD LDFQIRKDFL YLGANVQYMR V
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
基因功能參考文獻(xiàn)：
1. The LBP gene is a macrophage-specific LXR target that promotes foam cell survival and atherogenesis. PMID: 24671012
2. LBP is a critical factor in the development of non-alcoholic fatty liver disease. PMID: 27404046
3. LBP is a proinflammatory soluble adipokine that acts as a brake for adipogenesis, strengthening the negative effects of palmitate and LPS on adipocyte differentiation. PMID: 26201685
4. Differential expression of LBP and TGFB1, along with other genes, in different mesenchymal stromal cells preparations, produces the variable responses to external stimuli. PMID: 24664302
5. findings describe a novel role for LBP in normal hippocampal development and raise the possibility that some of the behavioral sequelae of early life stress are mediated by reduced expression of LBP during a critical period of neurodevelopment. PMID: 21993208
6. The amino acid sequence for two mimic epitopes of the inflammatory site of LBP were determined to be WKAQKRFMKKSG and LKTRKLFWKYKD. PMID: 20833181
7. LBP plays an important role in early alcohol-induced liver injury by enhancing LPS-induced signal transduction, most likely in Kupffer cells. PMID: 11884468
8. LBP plays an important role in resistance to lethal Salmonella peritonitis (but not to oral or intravenous infection) by facilitating the role of neutrophils in mediating acute inflammation. PMID: 12055258
9. role LBP plays in local pulmonary immune defenses to bacterial challenge PMID: 12353926
10. In the case of intraperitoneal infection of LBP-deficient mice with Salmonella typhimurium, no local inflammatory response is evident, neutrophil influx is delayed, and the mice succumb to the infection. PMID: 12370383
11. plays an essential role in the innate immune response to Gram-positive pneumococci PMID: 12932360
12. Locally produced LBP is an essential component of an effective innate immune response to E. coli peritonitis. PMID: 14638760
13. LBP is one of the critical molecules regulating the acute and chronic airway response to inhaled lipopolysaccharides (LPS). PMID: 15356561
14. LBP knockout mice are protected from toxicity with a decrease in hepatic necrosis following acetaminophen challenge. This suggests a novel role for LBP in modulating acetaminophen-induced liver injury. PMID: 15619225
15. LBP does not contribute to an effective host response in Mycobacterium tuberculosis infection in mice. PMID: 15993364
16. LBP per se possesses a protective effect on acute necrotizing pancreatitis PMID: 16163057
17. In conclusion, hemorrhagic shock and resuscitation to mice cause severe, LBP-mediated hepatocellular damage. PMID: 16614372
18. Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition. PMID: 18559343
19. LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction. PMID: 18948440
20. Marked concomitant increases in plasma LBP and endotoxin-like activity following murine trypanosome infection might play an important role in the pathogenesis of trypanosomosis PMID: 19022463
21. Paneth cells express LBP together with other proteins acting in the innate immune response of the gut, such as lysozyme, defensins and intelectin. PMID: 19234712
22. Innate defense against lethal peritoneal infection with Salmonella requires the direct proinflammatory involvement of LPS-binding protein (LBP), a major nonredundant function of LBP in this model. PMID: 11466385
顯示更多

收起更多
亞細(xì)胞定位：

Secreted. Cytoplasmic granule membrane.
蛋白家族：

BPI/LBP/Plunc superfamily, BPI/LBP family
數(shù)據(jù)庫鏈接：

KEGG: mmu:16803

STRING: 10090.ENSMUSP00000016168

UniGene: Mm.218846