Recombinant Mouse Paired immunoglobulin-like receptor B (Pirb), partial

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中文名稱：

小鼠Lilrb3重組蛋白
貨號：

CSB-MP012941MO2
說明書：

MSDS Datasheet
規格：

￥3540
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Pirb
Uniprot No.：

P97484
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

Mammalian cell
分子量：

70.8 kDa
表達區域：

25-642aa
氨基酸序列

SLPKPILRVQPDSVVSRRTKVTFLCEETIGANEYRLYKDGKLYKTVTKNKQKPENKAEFSFSNVDLSNAGQYRCSYSTQYKSSGYSDLLELVVTGHYWTPSLLAQASPVVTSGGYVTLQCESWHNDHKFILTVEGPQKLSWTQDSQYNYSTRKYHALFSVGPVTPNQRWICRCYSYDRNRPYVWSPPSESVELLVSGNLQKPTIKAEPGSVITSKRAMTIWCQGNLDAEVYFLHNEKSQKTQSTQTLQEPGNKGKFFIPSVTLQHAGQYRCYCYGSAGWSQPSDTLELVVTGIYEYYEPRLSVLPSPVVTAGGNMTLHCASDFPYDKFILTKEDKKFGNSLDTEHISSSGQYRALFIIGPTTPTHTGAFRCYGYYKNAPQLWSVPSALQQILISGLSKKPSLLTHQGHILDPGMTLTLQCFSDINYDRFALHKVGGADIMQHSSQQTDTGFSVANFTLGYVSSSTGGQYRCYGAHNLSSEWSASSEPLDILITGQLPLTPSLSVQPNHTVHSGETVSLLCWSMDSVDTFILSKEGSAQQPLRLKSKSHDQQSQAEFSMSAVTSHLSGTYRCYGAQDSSFYLLSSASAPVELTVSGPIETSTPPPTMSMPLGGLHMYLK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
基因功能參考文獻：
1. Loss of gp91 is associated with Bone resorption. PMID: 27897222
2. Results imply a neuron-specific, cell-autonomous action of PirB on synaptic density in L2/3 pyramidal cells of visual cortex; suggest that PirB is needed to match spine density and excitatory synaptic function to activity levels within cortical circuits, thereby providing headroom for the cell to encode additional experiences at new synapses. PMID: 27752542
3. peripheral CD4+ T cells from spontaneous murine arthritis model frequently express PIR-B PMID: 28664612
4. These results provide evidence for a critical role of the major histocompatibility complex class I/PirB signaling system in the generation of asymmetries in hippocampal circuitry. PMID: 28594961
5. These data identify paired Ig-like receptor B as a molecular checkpoint in IL-13-induced eosinophil accumulation and activation PMID: 27324131
6. the overexpression of PirB inhibits the neuronal survival through increased neuron apoptosis PMID: 27443384
7. neural plasticity in adult visual cortex is actively repressed and can be enhanced by blocking PirB function. PMID: 25320232
8. The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling. PMID: 24278366
9. PIRB and LILRB2 were expressed in mouse and human platelets, respectively. PMID: 25075127
10. NogoA receptors, NogoR1 and PirB, are expressed in the ventricular zone where neural stem cells reside. PMID: 24449409
11. PirB expression is up-regulated after transient focal cerebral ischaemia. It may play pathologic roles in the inhibition of axonal regeneration after stroke. PMID: 23927735
12. PirB normally regulates spine and excitatory synapse density and consequently the threshold for new learning throughout life. PMID: 24302763
13. In mice, the deleterious effect of Abeta oligomers on hippocampal long-term potentiation required PirB, and in a transgenic model of Alzheimer's disease, PirB not only contributed to memory deficits present in adult mice, but also mediated loss of synaptic plasticity in juvenile visual cortex. PMID: 24052308
14. a key role for PIR-B in IPF, likely via the regulation of macrophage activation PMID: 23258232
15. study indicates an unexpected functional significance of classical immune-inhibitory receptors in maintenance of stemness of normal adult stem cells and in support of cancer development PMID: 22660330
16. findings, coupled with previous studies, may imply that PirB is probably a critical molecule in inhibition of axonal regeneration by myelin inhibitors after ON injury PMID: 22102155
17. This study demonistrated that significant neuroprotection in the absence of the innate immune receptor PirB in mice model of stroke. PMID: 22445338
18. the p75 receptor is required for the signal transduction of PIR- PMID: 21881600
19. the major promoter of Pirb, and probably Pira as well, is activated dominantly by PU.1 and marginally by Runx3 in B cells. PMID: 21555536
20. a novel mechanism by which PIR-B-mediated regulation is achieved differentially but competitively via MHCI and Nogo in cells of the immune system PMID: 21636572
21. Thus, PIR-B associated with Trk to downregulate basal and neurotrophin-regulated Trk activity through SHP-1/2 in neurons. PMID: 21364532
22. myeloid-derived suppressor cells genetically ablated for PIR-B underwent a specific transition to M1-like cells when entering the periphery from bone marrow, resulting in decreased suppressive function, regulatory T cell activation activity. PMID: 21376641
23. PIR-B is an important regulator of innate immunity mediated by TLR9 in B-1 cells, which can otherwise provoke autoimmunity when overactivated (Review) PMID: 20976309
24. PIR-B knock-out is not sufficient to induce extensive axonal regeneration after spinal cord injury. PMID: 21087927
25. PirB and Nogo receptor-1 participate in ligand-dependent inhibition of synaptic plasticity in hippocampal slice cultures of adult mice. PMID: 20844138
26. Blocking the function of PirB is not sufficient to promote axonal reorganization or functional recovery after motor cortex injury. PMID: 20881122
27. PIR-B negatively regulates macrophage functions in response to pathogenic bacteria and chronic intestinal inflammatory responses. PMID: 20398663
28. PIR-B is critical for B cell suppression, DC maturation and for balancing T(H)1 and T(H)2 immune responses. PMID: 12021780
29. HLA-G inhibits the functions of murine dendritic cells via the PIR-B immune inhibitory receptor. PMID: 12207326
30. Mast cell regulation via paired immunoglobulin-like receptor PIR-B. Review. PMID: 12403357
31. PIR-B plays a role in regulating signal strength in adhesion-mediated activation of myeloid cells. PMID: 15494528
32. Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR- PMID: 15723811
33. PirB, a major histocompatibility complex class I (MHCI) receptor, is expressed in central nervous system neurons and functions to limit the extent of experience-dependent plasticity in the visual cortex throughout life PMID: 16917027
34. We identify murine-paired Ig-like receptor (PIR)-B, and its human orthologs Ig-like transcript 2 and Ig-like transcript 5 as novel receptors for Staphylococcus aureus. PMID: 17371981
35. constitutive cis binding between LILRB2 or PIR-B and major histocompatibility complex class I has an essential role in regulating allergic responses PMID: 17420263
36. These findings indicate that sialylated O-linked sugar structures on CD99 play an important role in the recognition of PILR. PMID: 18209065
37. a single receptor can have dual functionality in distinct cell types after unique cellular signals PMID: 18316626
38. paired Ig-like receptor (PIR)-B, an MHC-I receptor expressed on antigen-presenting cells, can regulate CTL triggering by blocking the access of CD8 molecules to MHC-I PMID: 18787130
39. Deletion of PIR-B does not significantly alter either osteoclast or osteoblast function in vivo, at least up to 6 mo of age. PIR-B-deficient mice are not osteoporotic. PMID: 18802077
40. study found PirB, which has been implicated in nervous system plasticity, is a high-affinity receptor for Nogo, MAG, and OMgp; results implicate PirB in mediating axonal regeneration block PMID: 18988857
41. T cell expression of PIR-B with the cis-interacting MHC class I is strictly prohibited in periphery so as to secure prompt immune responses. PMID: 19684158
42. PIR-B on relatively primitive B cells, B-1 cells, suppresses TLR9 signaling via Bruton's tyrosine kinase (Btk) dephosphorylation, blocking the production of natural IgM antibodies. PMID: 19687229
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
組織特異性：

Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells.
數據庫鏈接：

KEGG: mmu:18733

STRING: 10090.ENSMUSP00000077546

UniGene: Mm.326531