Recombinant Mouse Interleukin-23 receptor (Il23r), partial

中文名稱：

小鼠Il23r重組蛋白
貨號：

CSB-YP814324MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Il23r重組蛋白
貨號：

CSB-EP814324MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Il23r重組蛋白
貨號：

CSB-EP814324MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Il23r重組蛋白
貨號：

CSB-BP814324MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Il23r重組蛋白
貨號：

CSB-MP814324MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Il23r
Uniprot No.：

Q8K4B4
別名：

Il23rInterleukin-23 receptor; IL-23 receptor; IL-23R
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
基因功能參考文獻：
1. Results suggest that the use of vectors carrying Soluble Interleukin-23 Receptor (sIL-23R) to block the interleukin-23/IL-23R interaction may be a new therapeutic strategy for the treatment of multiple sclerosis. PMID: 28593439
2. RBPJ binds and trans-activates the Il23r promoter and induces IL-23R expression and represses anti-inflammatory IL-10 production in Th17 cells. PMID: 27346359
3. Epithelial IL-23R signaling enables protective IL-22 responses in experimental colitis. PMID: 27524624
4. Study highlights the importance of IL-23R expression level and the instability of Foxp3+ regulatory T cells in the development of inflammatory bowel diseases. PMID: 27498708
5. Differential splicing generates antagonistic soluble IL-23R (sIL-23R) variants, which might limit IL-23-mediated immune responses. Here, ectodomain shedding of IL-23R was identified as an alternative pathway for the generation of sIL-23R. PMID: 26961870
6. Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma. PMID: 26242299
7. IL-23 plus T-cell receptor signalling results in significant upregulation of IL-23 receptor expressed predominantly on CD4(hi)CD8(hi)CD3(+)alphabetaTCR(+) thymocytes, and leads to RORgammat-dependent apoptosis. PMID: 25001511
8. Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota. PMID: 25201978
9. Characterization of potent IL-23R small-peptide modulator, 2305 (teeeqqly), that decreases inflammatory response. PMID: 25354400
10. Although they share a common subunit, IL-23 and IL-12 receptors are not expressed on the same cell populations PMID: 24586521
11. IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism. PMID: 23715173
12. the balance between the enhancing and inhibitory effects of gamma-delta T cells is regulated by their level of IL-23R expression. PMID: 23797670
13. Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor. PMID: 23673666
14. study indicates the importance of IL-23 pathway in Th17 development and the negative regulation of Th17 development by IL23R-CHR PMID: 23029144
15. The IL-23 receptor is necessary for lymphoid hyperplasia, production of pathogenic autoantibodies, and infiltration of kidneys by IL-17-expressing cells in lupus-prone mice. PMID: 20308633
16. suppression of T-bet ameliorates EAE by limiting the differentiation of autoreactive Th1 cells, as well as inhibiting pathogenic Th17 cells via regulation of IL-23R. PMID: 17237380
17. IL-23R deficiency inhibited terminal differentiation of interleukin 17-producing effector T helper cells. PMID: 19182808
18. These results suggest that the induction of IL-23R and Th17 differentiation by IL-6 and IL-23 is mediated through endogenously produced TGF-beta. PMID: 19501566
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Type I cytokine receptor family, Type 2 subfamily
組織特異性：

Expressed by Th1, Th2 and dendritic cells.
數(shù)據(jù)庫鏈接：

KEGG: mmu:209590

STRING: 10090.ENSMUSP00000113342

UniGene: Mm.221227