Recombinant Mouse Homeobox protein Mohawk (Mkx)

中文名稱：

小鼠Mkx重組蛋白
貨號：

CSB-YP806846MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Mkx重組蛋白
貨號：

CSB-EP806846MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Mkx重組蛋白
貨號：

CSB-EP806846MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Mkx重組蛋白
貨號：

CSB-BP806846MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Mkx重組蛋白
貨號：

CSB-MP806846MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mkx
Uniprot No.：

Q8BIA3
別名：

Mkx; Homeobox protein Mohawk
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-353
氨基酸序列

MNTIVFNKLG GAVLFEDRGT PDRERGSRTF SGFLDNPHTG PEVGIPDGPP LKDNLSLRHR RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK TEKILLALGS QMTLVQVSNW FANARRRLKN TVRQPDLSWA LRIKLYNKYV QGNAERLSVS SDGDSCSEDG ENPPRNHMNE EGYSTPAHHT VIKGESSAIK AGGRPESRAA EDYVSPPKYK SSLLNRYLND SLRHVMATST AMMGKTRRRN HSGSFSSNEF EEELVSPSSS ETEGTFVYRT DTPDIGSTKG DSAANRRGPS KDDTYWKEIN AAMALTNLAQ GKDEVQGTTS CIIQKSSHIA EVKTVKLPLV QRF
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation.
基因功能參考文獻(xiàn)：
1. Data show that homeobox protein Mohawk (Mkx) is mainly expressed in the outer annulus fibrosus (OAF) of humans and mice. PMID: 27527664
2. accelerates tendon differentiation and prevents chondrogenic/osteogenic differentiation PMID: 27370800
3. Mkx prevents periodontal ligament degeneration by regulating osteogenesis. PMID: 27993989
4. Gtf2ird1 is essential for Mkx transcription, while also linking mechanical forces to Mkx-mediated tendon homeostasis and regeneration. PMID: 26884464
5. these data shed light on previously unrecognized roles of Mkx in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFbeta pathway. PMID: 25332192
6. Mkx is an important regulator of the differentiation of VPs and pulleys, as well as of tendon differentiation. PMID: 24166359
7. Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization. PMID: 23653374
8. these data identify the unique DNA-recognition properties of MKX and reveal a novel role for Mkx in promoting slow fiber type specification during skeletal muscle differentiation. PMID: 22923612
9. These results suggest that Irxl1 is required for the tendon differentiation but dispensable for the patterning of the musculoskeletal system in development. PMID: 21254332
10. Mkx mRNA was strongly expressed in differentiating tendon cells during embryogenesis and in the tendon sheath cells in postnatal stages. In addition to defects in tendon collagen fibrillogenesis, Mkx(-/-) mice exhibited abnormal tendon sheaths. PMID: 20696843
11. observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. PMID: 20498044
12. Mohawk is an important regulator of vertebrate development. PMID: 16408284
13. The developmental expression pattern indicates that Irxl1 is a good candidate gene for the Twirler gene. PMID: 16426902
14. Irxl1 is a newly identified highly divergent member of the Irx gene family with specific expression patterns in embryogenesis. PMID: 16824806
15. Mohawk can repress transcription through recruitment of the Sin3A/HDAC co-repressor complex PMID: 19235719
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

TALE/IRO homeobox family
數(shù)據(jù)庫鏈接：

KEGG: mmu:210719

STRING: 10090.ENSMUSP00000078718

UniGene: Mm.257186