Recombinant Mouse Hephaestin (Heph), partial

中文名稱：

小鼠Heph重組蛋白
貨號(hào)：

CSB-YP010289MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Heph重組蛋白
貨號(hào)：

CSB-EP010289MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Heph重組蛋白
貨號(hào)：

CSB-EP010289MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Heph重組蛋白
貨號(hào)：

CSB-BP010289MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Heph重組蛋白
貨號(hào)：

CSB-MP010289MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Heph
Uniprot No.：

Q9Z0Z4
別名：

Heph; Kiaa0698Hephaestin; EC 1.-.-.-
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.
基因功能參考文獻(xiàn)：
1. In mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels. Both neurons and glia degenerate and mice become ataxic unless given an iron chelator. PMID: 26303407
2. The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice. PMID: 24896847
3. Data (including data from studies in knockout mice) suggest that hephaestin and ceruloplasmin play distinct roles in regulation of gene expression in various regions of the brain and are involved in iron homeostasis. PMID: 25788583
4. results show that Heph is expressed by oligodendrocytes and plays an important role in iron efflux from these cells. PMID: 21917813
5. Hephaestin and Ireg1 expression respond to systemic rather than local signals of iron status. PMID: 12730111
6. Hephaestin has both amine oxidase and ferroxidase activity primary intestinal enterocytes and may facilitate iron export from intestinal enterocytes; also activity and structural studies of truncated Heph in sla mice PMID: 14751926
7. Copper is required for the proper processing and/or stability of hephaestin. PMID: 16614410
8. Expression of hephaestin (Heph) increased significantly in cerebral cortex and caudate putamen of old (80-week-old), ceruloplasmin-deficient (CP-/-) mice; expression of Heph was unaltered in substantia nigra and cerebellum. PMID: 19747625
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相關(guān)疾病：

Defects in Heph are a cause of the sex-linked anemia (sla) that is characterized by moderate to severe microcytic hypochronic anemia.
亞細(xì)胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Multicopper oxidase family
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:15203

STRING: 10090.ENSMUSP00000033553

UniGene: Mm.277092