Recombinant Mouse Hepatocyte nuclear factor 1-beta (Hnf1b)

中文名稱：

小鼠Hnf1b重組蛋白
貨號：

CSB-YP010593MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Hnf1b重組蛋白
貨號：

CSB-EP010593MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Hnf1b重組蛋白
貨號：

CSB-EP010593MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Hnf1b重組蛋白
貨號：

CSB-BP010593MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Hnf1b重組蛋白
貨號：

CSB-MP010593MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Hnf1b
Uniprot No.：

P27889
別名：

Hnf1b; Hnf-1b; Tcf2; Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; Homeoprotein LFB3; Transcription factor 2; TCF-2
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-558
氨基酸序列

MVSKLTSLQQ ELLSALLSSG VTKEVLIQAL EELLPSPNFG VKLETLPLSP GSGADLDTKP VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT EEAAEQRAEV DRMLSEDPWR AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL SQHLNKGTPM KTQKRAALYT WYVRKQREIL RQFNQTVQSS GNMTDKSSQD QLLFLFPEFS QQNQGPGQSE DTCSEPTNKK MRRNRFKWGP ASQQILYQAY DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF ANRRKEEAFR QKLAMDAYSS NQTHNLNPLL THGSPHHQPS SSPPNKMSGV RYNQPGNNEV TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHSLLSPDS KMQITVSGGG LPPVSTLTNI HSLSHHNPQQ SQNLIMTPLS GVMAIAQSLN TSQAQGVPVI NSVASSLAAL QPVQFSQQLH SPHQQPLMQQ SPGSHMAQQP FMAAVTQLQN SHMYAHKQEP PQYSHTSRFP SAMVVTDTSS INTLTSMSSS KQCPLQAW
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1.
基因功能參考文獻：
1. Loss of HNF1B in renal epithelial cells Results in Kidney Disease with Cysts. PMID: 29735694
2. HNF1beta renal knockout mouse exhibits down-regulation of Kcnj16.Thus, HNF1beta is a transcriptional activator of Kcnj16. PMID: 28577853
3. Results provide evidence that downregulation of HNF1b and activation of reactive oxygen species/NF-kappaB-mediated in fl ammation play an important role in PCB-153-induced glucose/lipid metabolic disorder. PMID: 28285191
4. Hnf1b deletion leads to massively mispatterned ureteric tree network, defective collecting duct differentiation and disrupted tissue architecture, which leads to cystogenesis. This study uncovers a fundamental and recurring role of HNF1B in epithelial organization during early ureteric bud branching and in further patterning and differentiation of the collecting duct system in mouse. PMID: 29158444
5. This review discusses the role of HNF1B in human and murine pancreas and liver development, summarizes the disease phenotypes and identifies areas for future investigations in HNF1B-associated diabetes and liver disease. [Review Article] PMID: 27615128
6. role in osmoregulation in renal collecting ducts PMID: 28507058
7. These results demonstrated the crucial role of Hnf1b and Foxa3 in hepatogenesis in vitro and provided a valuable tool for the efficient differentiation of HLCs from ES cells. PMID: 27107701
8. HNF-1beta Regulates MicroRNA-200 Expression through a Long Noncoding RNA PMID: 26292219
9. TNFalpha regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta-mediated expression of uromodulin. PMID: 25503683
10. Hypoxia induced early up-regulation of Hnf-1beta from 1 to 24 hours, independently of the hypoxia-inducible factor Hif-1alpha. PMID: 23704921
11. Zyxin regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1beta. PMID: 23657850
12. HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. PMID: 23362348
13. Hepatocyte nuclear factor 1beta controls nephron tubular development. PMID: 23362349
14. identification of Hnf1b as a target of miR-802-dependent silencing; show that short hairpin RNA (shRNA)-mediated reduction of Hnf1b in liver causes glucose intolerance, impairs insulin signalling and promotes hepatic gluconeogenesis PMID: 23389544
15. Hnf1b and Pax2 operate to control kidney morphogenesis and ureter differentiation. PMID: 22511595
16. Overexpression of HNF1beta resulted in accelerated cell proliferation with the protein level up-regulation of plasminogen and plasmin, a converted active form of plasminogen, which play a pivotal role in liver regeneration inducing hepatocyte proliferation. PMID: 21385055
17. Study identifies new direct target genes of the Hnf1b transcription factors and shows that they play crucial roles in both defining cell fate and controlling terminal functions in the gut epithelium. PMID: 20388655
18. transcriptional hierarchy between HNF-1beta and PKD (polycystic kidney disease) genes expressed in the primary cilia of collecting duct cells has been suggested, and collectrin is one of such HNF-1beta regulated genes PMID: 17476336
19. inactivation does not elicit cystic dilation in cystic tubules after their proliferative morphogenetic elongation is complete, giving rise to cysts PMID: 19966811
20. The results demonstrate that vHNF1 plays a crucial role during the earliest stages of urogenital development and provide novel insights into the regulatory circuits controlling events. PMID: 20040500
21. These data suggest a requirement for HNF1beta in biliary epithelium formation from the onset of the biliary system development. PMID: 11934849
22. mutations of HNF-1beta may cause dysregulated ksp-cadherin promoter activity PMID: 12217876
23. pathogenic consequences of mutations within the HNF-1 beta gene by mRNA analysis. PMID: 15085338
24. HNF1beta is involved in regulating the beta-cell transcription factor network and is necessary for glucose sensing or glycolytic signaling. PMID: 15142986
25. Expression profile analysis with mouse cDNA microarrays detected 243 genes whose expression levels were decreased by >50% upon RNAi of HNF-1beta PMID: 15148361
26. the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain has a role in Pkhd1 (ARPKD) gene transcription and renal cystogenesis PMID: 15647252
27. Lack of TCF2 results in pancreas agenesis by embryonic day 13.5. PMID: 15668393
28. The largest series to date of HNF-1beta mutations and confirm HNF-1beta mutations as an important cause of renal disease. PMID: 15930087
29. These results suggest that expression of Hnf6 and Hnf1b is downstream of C/EBPalpha action in fetal liver development, and that the suppression of C/EBPalpha expression in periportal hepatoblasts may lead to expression of Hnf6 and Hnf1b mRNAs. PMID: 17021047
30. MAFB, which is itself regulated by vHNF1, acts as a positive modulator of vHnf1 in r5 and r6, whereas another MAF-related factor is absolutely required for the expression of vHnf1 in both the hindbrain and the spinal cord. PMID: 17669392
31. The expression of Hfn1b protein in the developing pancreas is reported. PMID: 17996499
32. Overexpression of HNF1beta along with HNF1alpha enhances the activity of OAT1 promoters. PMID: 18029548
33. HNF-1beta regulates tubulogenesis by controlling the levels of SOCS-3 expression. PMID: 18077349
34. vHNF1 plays crucial role at the earliest steps of liver induction: the acquisition of endoderm competence and the hepatic specification. PMID: 18635606
35. Renal transcription factors HNF1alpha, HNF1beta, and HIF-1 might be the central mediators of drug-induced kidney injury and adaptive response pathways. PMID: 18656965
36. HNF-1beta regulates transcription of the PKD modifier gene Kif12. PMID: 19005009
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亞細胞定位：

Nucleus.
蛋白家族：

HNF1 homeobox family
數據庫鏈接：

KEGG: mmu:21410

STRING: 10090.ENSMUSP00000021016

UniGene: Mm.7226