Recombinant Mouse Hepatic triacylglycerol lipase (Lipc)

中文名稱：

小鼠Lipc重組蛋白
貨號：

CSB-YP012974MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Lipc重組蛋白
貨號：

CSB-EP012974MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Lipc重組蛋白
貨號：

CSB-EP012974MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Lipc重組蛋白
貨號：

CSB-BP012974MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Lipc重組蛋白
貨號：

CSB-MP012974MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lipc
Uniprot No.：

P27656
別名：

Lipc; Hpl; Hepatic triacylglycerol lipase; HL; Hepatic lipase; EC 3.1.1.3; Lipase member C
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

23-510
氨基酸序列

GQGVGTEP FGRSLGATEA SKPLKKPETR FLLFQDENDR LGCRLRPQHP ETLQECGFNS SQPLIMIIHG WSVDGLLENW IWKIVSALKS RQSQPVNVGL VDWISLAYQH YTIAVQNTRI VGQDVAALLL WLEESAKFSR SKVHLIGYSL GAHVSGFAGS SMDGKNKIGR ITGLDPAGPM FEGTSPNERL SPDDANFVDA IHTFTREHMG LSVGIKQPIA HYDFYPNGGS FQPGCHFLEL YKHIAEHGLN AITQTIKCAH ERSVHLFIDS LQHSDLQSIG FQCSDMGSFS QGLCLSCKKG RCNTLGYDIR KDRSGKSKRL FLITRAQSPF KVYHYQFKIQ FINQIEKPVE PTFTMSLLGT KEEIKRIPIT LGEGITSNKT YSFLITLDKD IGELILLKFK WENSAVWANV WNTVQTIMLW GIEPHHSGLI LKTIWVKAGE TQQRMTFCPE NLDDLQLHPS QEKVFVNCEV KSKRLTESKE QMSQETHAKK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles. Also exhibits lysophospholipase activity. Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates. In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position.
基因功能參考文獻：
1. The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin beta-Receptor(LTbeta-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE-/-Irs2+/-HL-/- atheromas. PMID: 27172975
2. hepatic lipase KO mice had dyslipidemia including hypercholesterolemia, hypertriglyceridemia and increased non-esterified fatty acid levels. Also glucose intolerance, pancreatic and hepatic inflammation and steatosis. PMID: 26423094
3. Bone marrow (BM)-derived hepatic lipase mitigates the HDL-lowering, HDL-modulating, and cholesterol-raising effects of BM-derived cholesteryl ester transfer protein. PMID: 24818611
4. HL expressed by osteoblasts has an impact on osteoblast OPG expression and that lack of HL leads to increased bone mass. PMID: 24440515
5. Hepatic lipase and endothelial lipase influence molecular species of several classes of plasma lipids. PMID: 24777581
6. interaction of LIGHT with LTbetaR on hepatocytes, but not Kupffer cells, is sufficient to down regulate hepatic lipase expression and that this effect can be independent of LIGHT's costimulatory function. PMID: 23355893
7. Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties. PMID: 23328279
8. Data show a novel pathway involving HL hydrolysis of VLDL that activates PPARdelta through generation of specific monounsaturated fatty acids. PMID: 21750705
9. These results demonstrated that fatty acid synthase and hepatic lipase might be FXR-regulated genes in liver cells. PMID: 20373033
10. The additive effect of hepatic lipase and endothelial lipase on HDL metabolism but not macrophage reverse cholesterol transport in mice. PMID: 20558822
11. highly divergent effects of naturally occurring HL coding sequence variants on lipid and lipoprotein metabolism PMID: 19965617
12. HL deficiency protects against diet-induced obesity and its hepatic sequelae. PMID: 20056822
13. Data show that shows the arrangement of an evolutionarily conserved domain within LMF1 (DUF1222) that is essential to lipase maturation. PMID: 19783858
14. findings indicate that hepatic lipase is required for optimal reproductive performance PMID: 11906928
15. synthesized in peritoneal macrophages PMID: 11971936
16. indicate a role for hepatic lipase in clearing phospholipase/free cholesterol from the vesicular lipoproteins of phospholipid transfer protein knock out mice. PMID: 12117557
17. the determinants of cell surface binding exist within the carboxyl terminal 70 amino acids of hepatic lipase, of which the last five residues play an important role PMID: 12700335
18. Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice. PMID: 12897204
19. Not essential for diet-induced gallstone formation in mice. PMID: 12939599
20. hepatic lipase activity is influenced by epistatic interaction between two nonstructural loci on chromosomes 7 and 3 PMID: 15314098
21. The results demonstrate that hepatic lipase deficiency, like LDLR deficiency, blunts the adrenal response to chronic ACTH stimulation and suggest a novel role for hepatic lipase in adrenal physiology. PMID: 16368783
22. HL-deficiency delays the onset and/or progression of atherosclerosis via a SR-BI-independent mechanism PMID: 16397139
23. Establishment of an antiatherogenic role of the ligand-binding function of hepataic lipase in LDL receptor-deficient mice. PMID: 17071916
24. ciHL expression reduces atherosclerosis PMID: 17234195
25. Elevated PLTP activity lowers plasma HDL-cholesterol by stimulating the plasma turnover and hepatic uptake of HDL cholesteryl esters. PMID: 19524061
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亞細胞定位：

Secreted.
蛋白家族：

AB hydrolase superfamily, Lipase family
數據庫鏈接：

KEGG: mmu:15450

STRING: 10090.ENSMUSP00000034731

UniGene: Mm.390187