Recombinant Mouse H (+)/Cl (-) exchange transporter 7 (Clcn7), partial

中文名稱：

Recombinant Mouse H(+)/Cl(-) exchange transporter 7(Clcn7) ,partial
貨號：

CSB-YP005486MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse H(+)/Cl(-) exchange transporter 7(Clcn7) ,partial
貨號：

CSB-EP005486MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse H(+)/Cl(-) exchange transporter 7(Clcn7) ,partial
貨號：

CSB-EP005486MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse H(+)/Cl(-) exchange transporter 7(Clcn7) ,partial
貨號：

CSB-BP005486MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse H(+)/Cl(-) exchange transporter 7(Clcn7) ,partial
貨號：

CSB-MP005486MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Clcn7
Uniprot No.：

O70496
別名：

Clcn7; Clc7H(+)/Cl(-) exchange transporter 7; Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
基因功能參考文獻：
1. a mouse with a different osteopetrosis-causing mutation (Clcn7(F318L)), is defined. PMID: 28942122
2. ClC-7 may affect tooth development by directly targeting tooth cells, and regulate tooth eruption through DFC mediated osteoclast pathway. PMID: 26829236
3. ClC-7 is essential for osteoclasts to resorb craniofacial bones to enable tooth eruption and root development. PMID: 26346547
4. ClC-7 deficiency impacts the development of the dentition and calvaria, but does not significantly disrupt amelogenesis. PMID: 25663454
5. ClC-7 does not appear to be crucially involved in gastric acid secretion, which explains the absence of an osteopetrorickets phenotype in CLCN7-related osteopetrosis. PMID: 24103576
6. Findings in this knockout mouse model prove that osteopetrotic compression of the brain is not responsible for neuronal and retinal degeneration in CLCN7-deficient mice; rather, they suggest that neurotoxicity is most likely due to lysosomal dysfunction. PMID: 20448277
7. Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of chloride channel 7 to lysosomes. [ClC7] PMID: 21441306
8. Chloride channel 7 (Clcn7) deficient mice bear a close resemblance to the progressive neuropathologic phenotype of neuronal ceroid lipofuscinosis. PMID: 21107136
9. study of mice with a point mutation converting ClC-7 into an uncoupled (unc) Cl-conductor; findings show only some roles of ClC-7 Cl-/H+ exchange can be taken over by a Cl- conductance PMID: 20430974
10. Supports role of osteoclasts in tooth eruption, root development; suggest disordered homeostasis of odontogenic precursors is reason for odontoma-like growths. Genetic mapping narrowed location to genetic interval of 3.2 cM on mouse chromosome 17. PMID: 20121924
11. These experiments demonstrate that lysosomal pathology is a cell-autonomous consequence of ClC-7 disruption and that ClC-7 is important for lysosomal protein degradation. PMID: 19661288
12. ClC-7 knockout mice display neurodegeneration and severe lysosomal storage disease despite unchanged lysosomal pH in cultured neurons. PMID: 15706348
13. both ClC-7 and Ostm1 proteins co-localize in late endosomes and lysosomes of various tissues, as well as in the ruffled border of bone-resorbing osteoclasts PMID: 16525474
14. microphthalmia transcription factor regulates Clcn7 and Ostm1 expression in osteoclasts PMID: 17105730
15. bone formation and bone resorption are no longer balanced in ClC-7(-/-) mice PMID: 18958510
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亞細胞定位：

Lysosome membrane; Multi-pass membrane protein.
蛋白家族：

Chloride channel (TC 2.A.49) family, ClC-7/CLCN7 subfamily
組織特異性：

Liver, spleen, kidneys and brain.
數據庫鏈接：

KEGG: mmu:26373

STRING: 10090.ENSMUSP00000035964

UniGene: Mm.270587