Recombinant Mouse Filamin-binding LIM protein 1 (Fblim1)

中文名稱：

小鼠Fblim1重組蛋白
貨號：

CSB-YP744482MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Fblim1重組蛋白
貨號：

CSB-EP744482MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Fblim1重組蛋白
貨號：

CSB-EP744482MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Fblim1重組蛋白
貨號：

CSB-BP744482MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Fblim1重組蛋白
貨號：

CSB-MP744482MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Fblim1
Uniprot No.：

Q71FD7
別名：

Fblim1; CalFilamin-binding LIM protein 1; FBLP-1; CSX-associated LIM
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-375
氨基酸序列

MASKPEKRVA SSVFITLAPP RRDVAVSEEV GQAACEARRA RPWEMLPTKT PGAAVGRSPK TWTPSGKTNA SLSGVTPQLS NGGCSLPPPS LNEEDLDLPP PPPPPSAYLP LPEEEPPVLP GKSLISDLEQ LHLPPPPPPP PPQAPSKGSS VHPPPGHAIP SEEELPPPPE EPVTLPEREV STDVCGFCHK PVSPRELAVE AMKRQYHAQC FTCRTCRRQL AGQRFYQKDG RPLCEPCYQD TLEKCGKCGE VVQEHVIRAL GKAFHPPCFT CVTCARCISD ESFALDSQNQ VYCVADFYRK FAPVCSICEN PIIPRDGKDA FKIECMGRNF HENCYRCEDC SVLLSVEPTD QGCYPLNDHL FCKPCHLKRS AAGCC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.
基因功能參考文獻：
1. Suggest migfilin regulates cardiac hypertrophy in transverse aortic constriction. PMID: 25852081
2. C-terminal LIM domains of migfilin dictate its focal adhesion localization, and these domains mediate an interaction with kindlin in vitro and in cells, demonstrating that kindlin is important for normal migfilin dynamics. PMID: 24165133
3. results identify FBLP-1 as a key regulator of bone homeostasis and suggest that FBLP-1 functions in this process through modulating both the intrinsic properties of OB/BMSCs (i.e., BMSC-extracellular matrix adhesion and migration PMID: 22556421
4. This study demonistrated that a molecular mechanism whereby FlnA loss impaired G2 to M phase entry, leading to cell cycle prolongation, compromised neural progenitor proliferation, and reduced brain size. PMID: 22649246
5. The findings indicate that the roles of migfilin are functionally redundant during mouse development and tissue homeostasis. PMID: 21224394
6. results suggest that a novel LIM protein Cal induces cardiomyocyte differentiation through its dynamic intracellular shuttling and association with CSX/NKX2-5 PMID: 14757752
7. analysis of the migfilin-filamin interaction and competition with integrin beta 7 tails PMID: 18829455
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亞細胞定位：

Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber.
數據庫鏈接：

KEGG: mmu:74202

STRING: 10090.ENSMUSP00000006381

UniGene: Mm.490327