Recombinant Mouse Dendrin (Ddn)

中文名稱：

Recombinant Mouse Dendrin(Ddn)
貨號：

CSB-YP006592MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Dendrin(Ddn)
貨號：

CSB-EP006592MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Dendrin(Ddn)
貨號：

CSB-EP006592MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Dendrin(Ddn)
貨號：

CSB-BP006592MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Dendrin(Ddn)
貨號：

CSB-MP006592MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ddn
Uniprot No.：

Q80TS7
別名：

Ddn; Gm748; Kiaa0749; Dendrin
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-710
氨基酸序列

MLDGPLFSEG PDSPRELQDE ESGSCLWVQK SKLLVIEVKT ISCHYSRRAP SRQSMDIQAS YWARGPQSRT CRLRPGSPEP PPRRPWASRV LQEATNWRAG PPAEVRAREQ EKRKAASQER EAKETERKRR KAGGARRSPL GQPRPEPRNA LRAAQPTGFP VFSRPERFGQ VGRAPRPSVL PQGDPGVAWA GPWGGRRPGP PSYEAHLLLR GSAGTAPRRR WDRPPPYVAP PSYEGPHRTL GTKRGPELSR APTSSAPVPA TTRTEGGRTK KRLDPRIYRD VLGAWGLRQG RGLLGGAPGC TAARARPESC KGAIEKSSGL VAAGLNSAGD SHSQGKTTGG PGTDAALSRS AISSPPRPVP RSRQHLRGSR KGKEGSEQIW LPTCWLASPK KPPVRHSQTL PRPWAPGGTG WKESLGQREG AEHETLEVWK VTRRAHTLPR ISRGPAGREG IFVIDATCVV IKSQYVPTPR TQQGQLVPSG ESCSVSDSLS QPKPCHEEEG EGAAANPSVC QKRLLSSRVL NQPSEGRECE AEVGQQGDSS LEERSSSGLG FPVGEVNPRD APTQPGSQEH PTLGPAAPVC AGSLKGSEAA GVPRRAGGGW ARTPGPYAGA LREAVSRIRR HTAPDSDSDE AEDLSVHSGS SDGSDTDAPG ASWRNERTLP ALGNTRPREG GKTAGLSDSI REIVDVISQT EEGFIREDTR KTPQGNRERE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein.
基因功能參考文獻：
1. ablation of the podocyte death-promoting protein dendrin delays onset of end-stage kidney disease, thereby expanding the life span of mice lacking the adapter protein CD2AP. Ablation of dendrin delays onset and severity of proteinuria and podocyte loss. PMID: 26073036
2. relocation of dendrin from the slit diaphragm to the podocyte nucleus in adriamycin-induced glomerulosclerosis PMID: 21606645
3. Nuclear relocation of dendrin promotes apoptosis of podocytes. PMID: 17537921
4. In glomerulogenesis, dendrin mRNA and protein appeared first at the early capillary loop stage. It was concentrated to the pre-podocytes on the basal side of podocalyxin, an apical cell membrane marker. PMID: 18356187
亞細胞定位：

Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Nucleus.
組織特異性：

Two forms of 81 kDa and 89 kDa are expressed in brain. The 81 kDa form is the only one found in kidney podocytes.
數據庫鏈接：

KEGG: mmu:13199

STRING: 10090.ENSMUSP00000074895

UniGene: Mm.390810

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